An Introduction to Genetic Epidemiology

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Lyle Palmer, Paul R. Burton, George Davey Smith
Policy Press, 2011 - Political Science - 230 pages
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Genetic epidemiology is a very rapidly developing field that has acquired a central role in modern biomedical science. Until now there has been no comprehensive introductory text for students and academics who do not have specialised training in statistics or genetics. This book begins with a primer in human molecular genetics and then examines standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field. Among much else, the book contains discussion of the public health aspects of the new genetics, and of epidemiological methods for studying genes and environmental factors in complex diseases.Written by leading international experts and supplemented by a glossary and in-chapter guides to further reading, this essential textbook will be widely welcomed by teachers and students on many courses internationally.
 

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Contents

Introduction
1
1 Key concepts in genetic epidemiology
5
2 Genetic linkage studies
39
3 Genetic association studies
61
4 Mapping complex disease genes using linkage disequilibrium and genome wide association scans
91
what makes a good genetic association study?
131
6 Biobanks and biobank harmonisation
155
genomic profiling personalised medicine and Mendelian randomisation
175
Glossary
217
Index
225
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About the author (2011)

Lyle J. Palmer, Western Australian Institute for Medical Research, University of Western Australia, Paul R. Burton, Department of Health Sciences and Department of Genetics, University of Leicester and George Davey Smith, Department of Social Medicine, University of Bristol

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