An Introduction to Genetic Epidemiology
Palmer, Lyle J., Burton, Paul R., George Davey Smith
Policy Press, May 31, 2011 - Medical - 230 pages
Genetic epidemiology is a very rapidly developing field that has acquired a central role in modern biomedical science. Until now there has been no comprehensive introductory text for students and academics who do not have specialised training in statistics or genetics. This book begins with a primer in human molecular genetics and then examines standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field. Among much else, the book contains discussion of the public health aspects of the new genetics, and of epidemiological methods for studying genes and environmental factors in complex diseases. Written by leading international experts and supplemented by a glossary and in-chapter guides to further reading, this essential textbook will be widely welcomed by teachers and students on many courses internationally.
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six Biobanks and biobank harmonisation
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ALDH2 allele frequencies American Journal approach biological C-reactive protein cancer candidate gene Cardon LR case-control studies causal Chapter chromosome clinical cohort studies common diseases complex disease complex traits confounding coronary heart disease Davey Smith detect disease genes disease risk effects environmental estimate example exposure gene discovery genetic association studies genetic epidemiology genetic variants genome-wide association studies genotyping error GWASs haplotype Human Genetics identified individuals interaction International HapMap Project International Journal Ioannidis Journal of Epidemiology Journal of Human Khoury Lancet large number linkage analysis linkage disequilibrium linkage studies loci locus LOD score mapping Mendelian randomisation meta-analysis methods multiple mutations Nature Genetics Nature Reviews Genetics Palmer LJ Pharmacogenetics phenotype population stratification population-based potential protein quantitative traits recombination region relative risk replication Risch sample sequence sibling single nucleotide polymorphisms Smith G study design susceptibility tag SNPs type 2 diabetes UK Biobank Wellcome Trust