An Introduction to the Blood-brain Barrier
This book is devoted to exploring the complexities of the blood-brain barrier. The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood. Transport kinetics and carrier-mediated processes are described, and the mechanism by which molecules can cross the barrier is discussed. Ways in which the barrier can be disrupted and opened are covered as well. Subsequent chapters in the book describe the transport of glucose and amino acids into the central nervous systems, cover recent findings by which peptides and proteins are able to gain entry or are excluded from the brain, and analyze models that can be used for investigating how the blood-brain barrier can be disordered in neurological disease processes.
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History and basic concepts
Transport of glucose and amino acids in the central nervous
Peptides and proteins
Functions of peptides in the brain
Peptide and protein interactions at the bloodbrain barrier
Regulation of protein transport
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Acta active transport affinity albumin amino acid transport amino acids amphetamine arginine arterial Begley binding Biol blood flow blood to brain blood-CSF barrier blood–brain barrier brain capillaries brain microvessels Brain Res brain tissue capillary carrier-mediated caudate nucleus cell membrane central nervous system cerebral cerebrospinal fluid choroid plexus choroidal epithelium compared concentration cortex Davson diffusion DSIP effects endocytosis endothelial cells enkephalins enzyme equation equilibration erythrocyte extracellular fluid extracellular space Figure flux function glycine guinea-pig hormone indicated influx inhibition inhibitor injection insulin ions isolated brain Kastin kinetics labelled lesion mannitol measured mechanism metabolic molecule nervous tissue Neurochem neurons neuropeptides neutral amino acids nucleoside Oldendorf Pardridge penetration peptides perfusion perfusion fluid permeability coefficient phosphorylation Physiol plasma protein rabbit rat brain ratio receptors regions Segal sodium solute Spector studies substances substrate sugar technique thymidine transfer transport from blood vasopressin ventricles ventriculocisternal perfusion vitro vivo Vmax Zloković