An Introduction to the Blood-brain BarrierThis book is devoted to exploring the complexities of the blood-brain barrier. The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood. Transport kinetics and carrier-mediated processes are described, and the mechanism by which molecules can cross the barrier is discussed. Ways in which the barrier can be disrupted and opened are covered as well. Subsequent chapters in the book describe the transport of glucose and amino acids into the central nervous systems, cover recent findings by which peptides and proteins are able to gain entry or are excluded from the brain, and analyze models that can be used for investigating how the blood-brain barrier can be disordered in neurological disease processes. |
Contents
History and basic concepts | 1 |
Transport of glucose and amino acids in the central nervous | 146 |
Peptides and proteins | 195 |
Transport of some precursors of nucleotides and some | 273 |
Experimental models in the study of the pathology of | 293 |
| 323 | |
Other editions - View all
An Introduction to the Blood-Brain Barrier Hugh Davson, Dsc,Ljubisa Rakic,Malcolm Segal No preview available - 2013 |
Common terms and phrases
Acta active transport affinity albumin amino acid transport amino acids amphetamine arginine arterial Begley binding blood flow blood to brain blood-brain barrier blood-CSF barrier brain capillaries brain extracellular brain microvessels Brain Res brain tissue capillary carrier-mediated caudate nucleus cell membrane central nervous system cerebral cerebrospinal fluid choroid plexus choroidal epithelium compared concentration cortex Davson diffusion DSIP effects endocytosis endothelial cells endothelium enkephalins enzyme equation equilibration extracellular fluid extracellular space Figure flux function glycine guinea-pig hormone indicated influx inhibition inhibitor injection insulin ions isolated brain Kastin kinetics lesion mannitol measured mechanism metabolic Michaelis-Menten min¹ molecule nervous tissue Neurochem neurons neuropeptides neutral amino acids Oldendorf Pardridge penetration peptides perfusion perfusion fluid permeability coefficient phosphorylation Physiol plasma protein rabbit Rakić rat brain ratio receptors regions Segal solute Spector studies substances substrate technique tight junctions transfer ventricles ventriculocisternal perfusion vitro vivo Vmax VP arginine Zloković