An Atlas of Alzheimer's Disease
M.J. de Leon, Heiko Braak
Taylor & Francis, Oct 15, 1999 - Medical - 149 pages
As the general population ages, the number of elderly patients with mild to severe cognitive impairments can be expected to increase. Improved recognition of the risks for future Alzheimer's Disease (AD), improved characterization of the natural history of AD, and the increased understanding of the neuropathy of AD will lead to early diagnosis and to developing effective treatments.
An Atlas of Alzheimer's Disease presents photographs, line drawings, charts, graphs, and text that identify heuristically useful stages of disease progression across behavioral, neuroimaging, and neuropathology research areas. The atlas closely examines the major pathological brain lesions in AD and provides an in-depth view of the neurofibrillary degeneration of AD and beta-amyloid deposits in the brain. It concisely covers current knowledge in the key areas of AD research, including clinical diagnostic features, and explores the clinical, anatomical, and pathological knowledge bases that have shaped our understanding of AD.
With its exceptional illustrations and contributions from leading research groups, An Atlas of Alzheimer's Disease provides a deeper understanding of the disease and the importance of early diagnosis and management.
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1999 Barry Reisberg 3-amyloid Acad Sci USA Acta Neuropathol activities allele Alzheimer disease amygdala amyloid deposits amyloid precursor protein angiopathy apo E4 apolipoprotein arrowed astrocytes Braak H Brain Res chromosome clinical cognitive cortical deficits dementia dentate gyrus e4 allele entorhinal cortex entorhinal region extracellular familial Alzheimer's disease fibril function gene genetic hippocampal atrophy hippocampal formation human impairment increased kinases labal late-onset layer lesions limbic M.D. Figure medial memory metabolism microglial cells microtubules molecular mutations Natl Acad Sci neocortex neocortical neuritic neuritic plaques Neurobiol Aging neurofibrillary changes neurofibrillary tangles neuroimaging Neurology neuronal neuronal loss neuropil neuropil threads NFTs normal aging normal elderly normal tau onset at age parahippocampal gyrus pathology peptide perirhinal phosphatases phosphorylation pocampal presenilin presubiculum Proc Natl Acad processes senile plaques specific sporadic stage structures studies subiculum syndrome tau protein temporal lobe tion transentorhinal vascular vitro vivo Wegiel Wisniewski HM