An Introduction to Molecular Medicine and Gene Therapy
An Introduction to Molecular Medicine and Gene Therapy Edited by Thomas F. Kresina, Ph.D. Gene therapy, or the use of genetic manipulation for disease treatment, is derived from advances in genetics, molecular biology, clinical medicine, and human genomics. Molecular medicine, the application of molecular biological techniques to disease treatment and diagnosis, is derived from the development of human organ transplantation, pharmacotherapy, and elucidation of the human genome. An Introduction to Molecular Medicine and Gene Therapy provides a basis for interpreting new clinical and basic research findings in the areas of cloning, gene transfer, and targeting; the applications of genetic medicine to clinical conditions; ethics and governmental regulations; and the burgeoning fields of genomics, biotechnology, and bioinformatics. By dividing the material into three sections - an introduction to basic science, a review of clinical applications, and a discussion of the evolving issues related to gene therapy and molecular medicine-this comprehensive manual describes the basic approaches to the broad range of actual and potential genetic-based therapies. In addition, An Introduction to Molecular Medicine and Gene Therapy: * Covers new frontiers in gene therapy, animal models, vectors, gene targeting, and ethical/legal considerations * Provides organ-based reviews of current studies in gene therapy for monogenetic, multifactoral or polygenic disorders, and infectious diseases * Includes bold-faced terms, key concepts, summaries, and lists of helpful references by subject in each chapter * Contains appendices on commercial implications and a review of the history of gene therapy This textbook offers a clear, concise writing style, drawing upon the expertise of the authors, all renowned researchers in their respective specialties of molecular medicine. Researchers in genetics and molecular medicine will all find An Introduction to Molecular Medicine and Gene Therapy to be an essential guide to the rapidly evolving field of gene therapy and its applications in molecular medicine.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Genetic Manifestations of Molecular Medicine
sents in broad general terms the diseases targeted by gene therapy and the tools
Gene Therapy and Molecular Medicine
35 other sections not shown
Other editions - View all
AAV vectors acid activity adenoviral adenoviral vector animal models antibodies antigen antisense apoptosis binding cancer cell cycle cell lines cell types cellular Chapter chromosome clinical trials cloned cytokines cytotoxic deletion disorders donor effect embryos encoding enzyme ethical ex vivo experimental fibroblasts function gene delivery gene expression gene product gene targeting gene therapy gene therapy approaches gene transfer genome graft growth factor hematopoietic hepatitis hepatocytes homologous human gene immune response infection inhibit integration levels liposomes liver lymphocytes mammalian mice molecules moral mRNA murine mutation neurons neurotrophic factors normal nuclear transplantation nucleus oligonucleotides oncogene packaging particles patients phenotype plasmid plasmid DNA potential promoter protein protocols RA-SF receptor recombinant regulatory replication retroviral vectors ribozymes sequence somatic specific stem cells strategies studies target cells therapeutic gene tion tissue trans transcription transduced transfection transgene tumor cells tumor suppressor gene vaccines viral vectors virus vitro wild-type