Anesthetic Toxicity

Front Cover
Susan A Rice
CRC Press, Jun 30, 1994 - Medical - 306 pages
1 Review
This text is a source of information on the toxicity of anaesthetic agents. The editors define toxicity in a broad sense to mean an adverse effect, whether that effect is the result of pharmacological, toxicological, physiological, or other mechanisms. They bring together reviews by experts in the disciplines concerned - including biochemistry, genetics, and immunology - involved in current research on these adverse effects.; The initial chapters provide an understanding of the factors responsible for toxicity, and the ways in which the adverse effects of anaesthetics can be investigated. Subsequent chapters cover topics such as: hepatotoxicity; nephrotoxicity; malignant hyperthermia triggered by anaesthetics; pulmonary effects of anaesthesia; toxicity of local anaesthetic agents; toxicity of nitrous oxide; immunosuppression in the postoperative period; and reproductive and developmental toxicity of anaesthetics. Many of the contributors offer insights into the anaesthetics and their interactions, such as the immunological effects of anaesthesia and the impact of pharmacogenetics.
 

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Contents

Anesthetic Toxicity An Overview
1
Animal Use in Toxicity Evaluation
9
Principles of Epidemiology for Evaluation of Anesthetic Toxicity
35
Metabolism of the Volatile Anesthetics
49
Hepatotoxicity of Halogenated Anesthetics
73
Nephrotoxicity of Volatile Anesthetic Agents
89
Toxicity of Local Anesthetic Agents
107
Toxicity of Nitrous Oxide
135
Reproductive and Developmental Toxicity of Anesthetics in Humans
175
Pharmacogenetics and Anesthetic Toxicity
199
Malignant Hyperthermia Triggered by Anesthetics
219
Immunosuppression in the Postoperative Period
241
Pulmonary Effects of Anesthesia
267
Biomarkers of Anesthetic Toxicity
281
Subject Index
297
Copyright

Reproductive and Developmental Toxicity of Anesthetics in Animals
157

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