Angiogenesis: From Basic Science to Clinical Applications
CRC Press, Aug 15, 2006 - Science - 280 pages
Why a new book on angiogenesis and why now? For the first time concepts proposed over 30 years ago have found clinical validation. In the last two years the first antiangiogenic agents have been approved by the FDA for the treatment of cancer and age-related macular degeneration. Not surprisingly, this clinical success has raised a new set of basic and clinical questions that need to be addressed.
Angiogenesis: From Basic Science to Clinical Applications presents the latest advances in basic science and reviews the status of the clinical applications of angiogenic growth factors and inhibitors. It explores current molecular and genetic findings on the regulation of angiogenesis, discusses the results of clinical trials and identifies the pathological conditions that are most likely to benefit from such treatments.
Edited by a leading researcher in the field, the book includes contributions from multiple experts in their respective disciplines, supplemented by illustrations and photographs. A unique combination of information on basic science and clinical trials research, this book is truly a state-of-the-art review of the state of the science.
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chapter two Signal transduction of VEGF receptors toward angiogenesis
chapter three Growth factors and lymphangiogenesis
chapter four Notch and vascular development
chapter five Neural guidance molecules in vascular development
chapter six Neuropilins receptors for the VEGF and semaphorin families link angiogenesis and axon guidance
chapter seven Nonangiogenic functions of VEGF
chapter eight Contribution of proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue
chapter nine Antiangiogenic drugs as broadly effective chemosensitizing agents
chapter ten Using an antiVEGF monoclonal antibody to treat cancer
chapter eleven Ocular neovascularization
chapter twelve Targeting VEGF for neovascular agerelated macular degeneration and macular edema
chapter thirteen Therapeutic angiogenesis for cardiovascular disease