Angiogenesis and Cardiovascular Disease

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J. Anthony Ware, Michael Simons
Oxford University Press, 1999 - Health & Fitness - 360 pages
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Angiogenesis and Cardiovascular Disease provides a comprehensive revie w of the basic scientific and clinical advances in the field of angiog enesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a single source. Topics addressed focus first on aspects of developmen t and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy of ischemic card iovascular disease. Vascular development, endothelial cell biology, th e vascular matrix, and growth factors are discussed. Up to date inform ation on current clinical trials, and practical advice concerning appl ication to cardiovascular therapeutic options, are also stressed.
 

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Contents

Developmental and Normal Biology of the Vasculature
3
Cellular Mechanisms of Angiogenesis
30
Heparan Sulfate Proteoglycans
60
Molecular Mechanisms of the Fibroblast Growth Factor
79
The Vascular Endothelial Growth Factor Family
101
PlateletDerived Growth Factor and Other Modulators
128
Angiogenesis in the Pathophysiology and Treatment
141
Collateral Circulation of the Heart
159
Angiogenesis in Nonischemic Myocardium
199
Animal Models of Angiogenesis in Cardiovascular Tissues
213
Growth Factor Delivery Strategies
238
Coronary Microcirculation and Angiogenesis
258
Therapeutic Angiogenesis in Myocardial Ischemia
289
Therapeutic Angiogenesis in Peripheral Limb Ischemia
321
Index
343
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About the author (1999)

J. Anthony Ware is at Albert Einstein College of Medicine, Bronx, New York. Michael Simons is at Harvard University School of Medicine; Director, Angiogenesis Research Center, Beth Israel Deaconess Medical Center, Boston.

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