Angiogenesis Inhibitors and Stimulators: Potential Therapeutic Implications
The regulation of blood vessel growth underlies many normal biological processes such as reproduction, development, repair and wound healing. It also is a critical feature of pathological processes such as cancer, diabetic retinopathy, macular degeneration, inflammatory arthritis and ischemic heart disease. What causes blood vessels to grow? What inhibits their growth? This book comprehensively describes the angiogenic proteins that enhance and inhibit normal and abnormal angiogenesis. It describes the potential therapeutic applications of basic fibroblast growth factor, vascular endothelial growth factor, PECAM-1 and thrombospondin as well as other factors. The book brings together information about new blood vessel formation in many organ systems and comprises an outstanding resource on the state-of-the art in angiogenesis.
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Potential Therapeutic Targets
Potential Therapeutic Applications of AntiAngiogenic Agents
The Role of Smooth Muscle Cells and Pericytes in Angiogenesis
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Acad Sci USA Angiogenesis Inhibitors angiogenic angiogenic factors antagonists antiangiogenic antibody aortic artery basement membrane basic fibroblast growth Batimastat bFGF binding Biochem Biol Chem blood vessels Cancer Res capillary carcinoma cell adhesion Cell Biol cell proliferation choroidal neovascularization Clin Invest clinical trials coronary diabetic disease domain endothelial cells endothelial growth factor endothelium extracellular matrix fibroblast growth factor function human hypoxia increased induced inhibit integrin integrin ov$3 interactions involved ischemia laminin ligand macrophages Matrigel matrix metalloproteinase mechanism mediated metastasis mice mitogenic molecules mRNA murine Natl Acad Sci Pathol pathway patients PECAM-1 peptide pericytes platelet potential Proc Natl Acad promotes protein receptor regulation release retinal neovascularization retinopathy role SIKVAV SMCs smooth muscle cells stimulate studies therapeutic therapy thrombospondin tissue transcription tube formation tumor tumor cells tumor growth tyrosine kinase upregulation vascular endothelial growth vascular permeability vascular smooth muscle VEGF gene VEGF mRNA vitro vivo wound healing