AngiotensinI.H. Page, F.M. Bumpus The history of arterial hypertension is both long and short; long, since BRIGHT (1827) first related hardness of the pulse to hardness of the kidneys and hyper. trophy of the heart; short in that modern research began in the late twenties. Most of what we know of these diseases has been discovered in the past fifty years. The modern story should have begun in 1897 when an extract of kidney was shown to be pressor. But little was done with knowledge until about 1929 when the relationship of this kidney extract called "renin" to hypertension was pos· tulated. The pressor effects were, however, unlike most of those seen with sub· stances such as epinephrine or vasopressin. Plasma was required for action of renin and the active substance appeared to be protein. In 1939, it was shown that renin was not in itself a pressor substance but rather a proteolytic enzyme which produced a powerful pressor substance acting on a substrate synthesized by the liver. Later it was noted that the first definable step after the formation of this peptide was cleaving of the decapeptide which had little or no demonstrable activity, with loss of two amino acids to form the octapeptide called "angiotensin". Within a decade synthesis was achieved which made the substance available for world·wide study. |
Contents
The Biological Production of Angiotensin LEONARD T SKEGGS FREDERIC E DORER | 1 |
Renin | 7 |
References | 13 |
Copyright | |
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acid Acta action adrenal aldosterone aldosterone secretion Amer amounts analogs angio animals antibodies appears arterial assay Biochem Biol biological blood pressure bradykinin BUMPUS caused cells changes chromatography Circulat circulation clin concentration contraction conversion converting enzyme CROXATTO demonstrated described determination dogs doses effect effect of angiotensin et al evidence experiments extracts factors flow formed fraction hormone human hypertension important inactivation increased incubation infusion inhibition inhibitor injection isolated KHAIRALLAH kidney levels liver lung measured mechanism method muscle Nature normal observed obtained occur patients peptide perfused Pharmacol Physiol plasma plasma renin position possible potassium preparation present pressor primary production protein purification rabbit recently receptor reduced release renal renin activity reported response separation serum showed similar smooth sodium solution specific stimulation studies substance substrate suggested synthesis Table tachyphylaxis technique tensin tissue values VANE vascular