Animal Clinical Chemistry: A Practical Handbook for Toxicologists and Biomedical Researchers, Second Edition

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G.O. Evans
CRC Press, Apr 29, 1996 - Medical - 224 pages
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By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science.
 

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Contents

1 General Introduction
1
2 Study Design and Regulatory Requirements
10
3 Preanalytical and Analytical Variables
19
4 Statistical Approaches
40
5 General Enzymology
54
6 Assessment of Hepatotoxicity
66
7 Assessment of Nephrotoxicity
83
8 Assessment of Endocrine Toxicity
95
11 Assessment of Neurotoxicity
149
12 Electrolyte and Fluid Balance
157
13 Lipids
172
14 Proteins
181
Abbreviations
193
APPENDIX I SI Units and Conversion Tables
195
APPENDIX II General References for Animal Clinical Chemistry Data
198
Index
200

9 Assessment of Gastrointestinal Toxicity and Pancreatic Toxicity
132
10 Assessment of Cardiotoxicity and Myotoxicity
141

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