Animal Models in Psychiatry, I

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Alan A. Boulton, Glen B. Baker, Mathew T. Martin-Iverson
Springer Science & Business Media, Aug 20, 1991 - Medical - 411 pages
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The two Animal Models in Psychiatry volumes are loosely organized by subject. The first volume contains a number of chapters concerned with schizophrenia, psyc- ses, neuroleptic-induced tardive dyskinesias, and other d- orders that may involve dopamine, such as attention deficit disorder and mania. The second volume deals with affective and anxiety disorders, but also includes chapters on subjects not easily classified as either psychotic, or affective, or an- ety-related, such as aggression, mental retardation, and memory disorders. Four chapters on animal models of schizophrenia or psychoses are included in the present v- ume because of the importance of these disorders in p- chiatry. Likewise, three chapters in the subsequent volume deal with depression. The first of the two volumes begins with an introd- tion by Paul Willner reviewing the criteria for assessing the validity of animal models in psychiatry. He has written - tensively on this subject, and his thorough description of the issues of various forms of validity provides a framework in which to evaluate the subsequent chapters. As will be seen, the remaining chapters in both volumes will refer frequently to these issues. The second chapter, by Melvin Lyon, describes a large number of different procedures that have been p- posed as potential animal models of schizophrenia. This is a departure from the usual format, consisting of detailed - scriptions of specific models.
 

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Contents

METHODS FOR ASSESSING THE VALIDITY
1
ANIMAL MODELS WITH PARALLELS TO SCHIZOPHRENIA
25
THE HPPOCAMPALLESDN MODEL OF SCHIZOPHRENIA
67
An Attentional Theory of Hippocampal Function
88
AN ANIMAL MODEL OF STIMULANT PSYCHOSES
103
Continuous Infusions with Day and Night Monitoring
116
Summary
142
Ellison
151
ANIMAL MODELS IN TARDIVE DYSKINESIA
245
AN ANIMAL MODEL
267
Conclusion
305
AN ANIMAL MODEL OF ATTENTION DEFICIT
313
The Effects of Amphetamine on LI
322
The Effects of Neuroleptics on LI
332
A COMPUTERIZED METHODOLOGY FOR THE STUDY
363
Index
399

ANIMAL MODELS FOR THE SYMPTOMS OF MANIA
197
Animal Models of Mania
204

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