Animal Models of T Cell-Mediated Skin Diseases
T. Zollner, Harald Renz, Khusru Asadullah
Springer Science & Business Media, Oct 7, 2004 - Science - 291 pages
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
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Pro and Antiinflammatory Effects of IL4 From Studies in Mice to Therapy of Autoimmune Diseases in Humans
What Must a Model Display for Proof as a Model of Contact Dermatitis?
Acute and Chronic Models of Allergic Contact Dermatitis Advantages and Limitations
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Previous Volumes Published in This Series
TCell Receptor Transgenic Models of Inflammatory Disorders Relevance for Atopic Dermatitis?