Animal Models of T Cell-Mediated Skin Diseases

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T. Zollner, Harald Renz, Khusru Asadullah
Springer Science & Business Media, Oct 7, 2004 - Science - 291 pages
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Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

 

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Contents

Making GeneModified Mice
1
HighThroughput Gene Knockouts and Phenotyping in Mice
27
Modelling GeneEnvironment Interactions in Th1 and Th2Dominated Diseases of Laboratory Animals
45
Animal Models of Experimental Asthma
69
Models of Rheumatoid Arthritis
89
Animal Models of Inflammatory Bowel Diseases
119
Marine Models of Atopic Dermatitis
133
Epicutaneous Sensitization with Allergens as an Atopic Dermatitis Model
167
What Must a Model Display for Proof as a Model of Psoriasis?
193
From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice
203
The Psoriasis SCID Mouse Model A Tool for Drug Discovery?
213
Pro and Antiinflammatory Effects of IL4 From Studies in Mice to Therapy of Autoimmune Diseases in Humans
235
What Must a Model Display for Proof as a Model of Contact Dermatitis?
243
Acute and Chronic Models of Allergic Contact Dermatitis Advantages and Limitations
255
Transgenic Mice Expressing IFN7 in the Epidermis Are a Model of Inflammatory Skin Disease and Systemic Lupus Erythematosus
277
Previous Volumes Published in This Series
293

TCell Receptor Transgenic Models of Inflammatory Disorders Relevance for Atopic Dermatitis?
175

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