Animal Toxins: Facts and Protocols

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Herve Rochat, Marie-France Martin-Eauclaire
Springer Science & Business Media, Mar 1, 2000 - Science - 365 pages
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It is now something of a truism to say that natural toxins form a major compo nent of the molecular tools used increasingly frequently by the ever growing number of laboratories of various kinds. Evidence for this is provided not only by the increasing number of firms including such toxins in their catalogues but also by the large number of demands received by those who discover new tox ins. This book is designed to facilitate the work of scientists interested in explor ing a new domain of toxicology or in using toxins as tools for research. The length of this book has been kept reasonable by concentrating on animal tox ins, most of which are polypeptides. The venom of each animal contains a large number of toxins, which may be similar in terms of their physical and chemical properties and are therefore difficult to purify. However, their pharmacological activities may be very differ ent. These toxins are extremely active, and it is therefore necessary to demon strate conclusively that the activity observed really does correspond to the newly characterized molecule.
 

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Contents

Contents
32
Toxin Isolation
38
Remarks
49
5
52
Conus Peptides and their Iodinated Derivatives as Probes
74
Introduction
81
Ant Polypeptide Toxins
90
Wasp Kinins and Kinin Analogues
99
Immunological Properties of Scorpion Toxins
169
Scorpion Toxins and Potassium Channels
183
Troubleshooting
193
Characterization of Animal Toxins Binding to Ionic Channels
217
The Fasciculins and their Interaction with
246
Dendrotoxins and BPTIlike Proteins
276
Cloning of mRNAs Encoding Sarafotoxin Precursors
293
Polypeptides and Proteins Active in the Coagulation Process
319

Mastoparan as a G Protein Activator
116
Pharmacologically Active Peptides and Proteins from Bee Venom
127
Purification and Characterization of Scorpion Toxins Acting
152
Guide to Solutions
347
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Page viii - WILLIAM R. KEM, Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

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