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Systemic Lupus Erythematosus
Nucleic Acid Structure and its Relationship to Immunogenicity
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Acad activity ammonium sulfate anti anti-DNA antibodies anti-dsDNA anti-nucleotide anti-sDNAmBSA antibody concentration antigen antigenic determinants antisera autoantibodies autoimmune BALB/c bases Biochem Biol calf thymus DNA Clin complexes conjugates coupling factors cross-reactive dCMP demonstrated denatured deoxynucleotides detected dGMP disease DNA binding double-stranded dsDNA dsDNA binding dsDNA-Sepharose dTMP eluted F1 hybrid Figure fragments hapten helical human SLE hybridoma I-sDNA idiotypic IgG fractions immune response immunogens immunoglobulin Immunol immunological incubated indicated inhibitor injected interactions kinetics modified Farr assay molecular monoclonal anti-DNA antibodies monoclonal antibodies murine NaCl nDNA nucleic acid nucleotides NZB mice NZB/W P]dsDNA PFC responses plasmid POLY poly(dA poly(dA-dT):poly(dA-dT poly(dA):poly(dT precipitation Proc protein purified rabbit reactivity relative Rheum sDNA serum shown single-stranded SLE patients SLE plasma SLE sera solid phase specific spleen cells ssDNA Stollar structure studies synthetic systemic lupus erythematosus Table thymus values Voss Zealand mice