Anti-Inflammatory Drugs in Asthma
For some years, international guidelines on the management of asthma have stressed the importance of early intervention with anti-inflammatory drugs to prevent acute asthma exacerbations and to avert chronic inflammatory damage to the airway. Introduced by a broad survey of the targets for anti-inflammatory drugs, this book proceeds to bring together the most recent research into the mechanisms and clinical benefits of presently available anti-inflammatory treatments including corticosteroids, cromones, and theophylline. For the first time, these drugs are discussed alongside the newly introduced leukotriene modifier drugs, and in the context of frontline research into anti-inflammatory drugs of the future. Leading authorities in their fields evaluate the prospects of novel anti-IgE agents and cytokine antagonists, and examine recent developments in immunosuppressant compounds, protease inhibitors, and selective phosphodiesterase inhibitors. This book is an up-to-date and authoritative survey which will be invaluable to university and pharmaceutical company researchers working on anti-asthma and anti-allergy drugs and to respiratory physicians keeping abreast of developments in their specialty.
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3-agonists adhesion molecules affinity airway inflammation airway responsiveness allergen allergen challenge allergen-induced Allergy Allergy Clin Immunol alveolar macrophages anti-inflammatory antibodies antigen asth asthmatic patients atopic Barnes PJ beclomethasone Biochem Biol Chem bronchial biopsies bronchoconstriction budesonide cAMP CD4+ chronic chymase clinical cromoglycate cyclic cytokines disease drugs effects of nedocromil endothelial cells enzyme eosinophils epithelial cells epithelium expression formoterol function gene glucocorticoids GM-CSF guinea pig histamine Holgate ST human lung human mast cell hyperreactivity immunosuppressive increased induced inflammatory cells inhaled corticosteroids inhibition interaction interleukin kinase leukocyte leukotriene leukotriene D4 lymphocytes macrophages mast cells mediators mice monocytes mRNA nedocromil nedocromil sodium neutrophils NF-kB oral corticosteroids PDE3 PDE4 inhibitors Pharmacol phosphodiesterase placebo potent protease protein reduced regulation release Resp Respir Crit Rev Respir role rolipram rolipram binding salbutamol salmeterol Schwartz LB severe asthma steroid studies therapy tion TNFo transcription factors treatment tryptase vitro Zardaverine