Antibiotic Discovery and Development

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Thomas J. Dougherty, Michael J. Pucci
Springer Science & Business Media, Dec 18, 2011 - Medical - 1127 pages
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This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
 

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Contents

Part II Marketed Major Classes of Compounds
78
Part III The Rise of Antibiotic ResistanceResistance Mechanisms to Major Classes
347
Part IV Clinical Issues of Resistance Worst Offenders List of Problematic Microbes
569
Part VI Mycobacteria
718
Part VII Antibiotic Discovery
752
Part VIII Antibiotic Drug Development
1068
Part IX The Economics and Incentives of Antibiotic Drug Discovery
1101
Index
1107
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