Antibiotic Resistance: Origins, Evolution, Selection and Spread

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Derek Chadwick, Jamie Goode
Wiley, Jun 19, 1997 - Medical - 250 pages
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Antibiotic Resistance: Origins, Evolution, Selection and Spread Chairman: Stuart B. Levy 1997 Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.

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an ecological imbalance
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P Huovinen H Seppälä J Kataja T Klaukka and the Finnish Study Group

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About the author (1997)

Jamie Goode, a former scientific editor, is wine writer for the "Sunday Express "and a contributor to magazines including "The World of Fine Wine" and "Wines & Vines". His website,, is one of the world s most visited wine sites. His first book, "The Science of Wine: From Vine to Glass" (UC Press) won the Glenfiddich Drink Book of the Year Award. Sam Harrop is a Master of Wine, qualified winemaker, and independent winemaking consultant. He co-founded Domaine Matassa and Litmus Wines, and is a co-chairman of the International Wine Challenge.

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