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Studies with Tetracycline Analogues
Resistance of Bacteria to the Tetracyclines
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30S ribosomal 30S subunit 50S ribosomal subunit Acad Acta actinomycin action of Sm activity alanine Amer amino acids antibacterial antibiotic assay aureus azaserine Bacillus subtilis Bact bacteria base pair binding of aminoacyl-tRNA binding of tetracycline Biochem Biol biophys carbomycin cell wall cell-free Chem chemical Chemother chloramphenicol chromophore complex concentration cultures cycloserine degradation DNA replication DNA synthesis doses drug effect enzyme erythromycin Escherichia coli ethambutol formation fusidic acid growth guanine hydrogen hypothesis inactivation incorporation infections inhibition inhibitory interaction isoniazid isonicotinic acid lincomycin mechanism of action messenger RNA metabolism miscoding mode of action molec molecule mutants mycin mycobacteria nalidixic acid novobiocin observed oleandomycin peptide pg/ml phage phenylalanyl-tRNA poly polymerase polysomes Proc protein biosynthesis protein synthesis purines puromycin pyrazinamide reaction resistance ribo ribonucleic acid ribosomes ristocetin sensitive serum specific spiramycin staphylococci strains strands streptomycin structure studies therapy transfer RNA tRNA tuberculostatic uptake vancomycin vitro vivo