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ANTIBIOTICS FROM SPONGES
ANTIBIOTICS FROM COELENTERATES
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A. K. Ganguly absorption acetate acetylation acid adriamycin afforded aglycone algae Amer analogues anthracyclines antibiotic antibiotic activity antimicrobial activity antitumour activity antitumour anthracyclines Arcamone aureus binding biological activity brominated Cancer carbonyl Chem chemical chromophore complex compounds configuration conformation converted D. J. Faulkner dauno daunomycin daunomycin and adriamycin daunosamine derivatives drug enzyme Equilibrium dialysis ester ether evermicose everninomicin everninose evernitrose evertetrose Fenical fluorescence gave glycosides hydrogen hydrolysis hydroxyl group interaction intercalation isolated ketone lactone latter linkage Marco marine MeO O OH MeOH metabolites methanol methoxyl group methyl mg/kg mice mixture moiety molecular molecule mycin N. R. Bachur n.m.r. spectrum NHCOCF O O OH obtained OH OH olgose OMe OMe oxidation phenols proton racemic reaction Reagents reduction reported ring Scheme shown shows the presence side chain ſold solvolysis spectra stereochemistry structure studies sugar synthesis Tetrahedron Letters tion tissues treatment yields