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ANTIBIOTICS FROM MICROORGANISMS
ANTIBIOTICS FROM SPONGES
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A. K. Ganguly absorption acetate acetylation acid adriamycin afforded aglycone algae Amer analogues anomeric proton anthracyclines antibiotic antibiotic activity antimicrobial activity antitumour activity antitumour anthracyclines Arcamone aureus bacteria binding brominated carbonyl Chem chemical colourless crystalline solid complex compound configuration converted D. J. Faulkner dauno daunomycin daunomycin and adriamycin daunosamine derivatives diazomethane drug enzyme ester evermicose everninomicin everninose evernitrose evertetrose evertriose Fenical flambamycin fluorescence followed gave gram positive hydrogen hydrolysis hydroxyl group infrared inhibited the growth intercalation isolated ketone lactone latter linkage Marco marine mass spectrum MeO 0 OH metabolites methanolic methoxyl methoxyl groups methyl methyl ether methyl glycoside mg/kg mice moiety molecular molecule mycin N. R. Bachur n.m.r. spectrum obtained OH OH olgose OMe OMe oxidation Permethylated phenols proton racemic reaction Reagents reduction reported Scheme shown shows the presence side chain sodium solvolysis spectra stereochemistry studies sugar synthesis Tetrahedron Letters tion tissues treatment