Antibiotics in Obstetrics and GynecologyWilliam J. Ledger The motive to prepare this volume on antibiotics for the physician caring for women was based upon the editor's perception that the subject matter had never been fully developed for the obstetrician-gynecologist. Most textbooks of infectious disease have a small section devoted to antibiotics, which has little relevance for the physician caring for post-operative or post-partum infections. Basic antibiotic pharmacology is described and there is a reflex prohibition of antibiotics for the pregnant woman. Correctly, the reader assumes that the authors themselves do not care for women with bacterial infections of the pelvis. Recent texts in infectious disease in obstetrics gynecology have been little better. Although the focus has been more clini cally oriented, space requirements have too often kept the discussions at a superficial level. A total focus upon antibiotics in this volume eliminates the restraints of space in prior publications. The greatest reward in my task as editor of this volume is related to the quality of the individual authors. They range from former students, to con temporary colleagues, to respected peers in infectious disease. Since the quality of this volume is related to the sum total of the individual chapters, I wish to comment about each of the contributors. Philip Mead from the University of Vermont is an old friend, who brings to the question of prophylactic antibiotics, his wide clinical experience and encyclopedic knowledge. |
Contents
Diagnosis and Treatment of SalpingoOophoritis | 101 |
Diagnosis and Treatment of the Patient with an Infected | 119 |
Tetracyclines and Penicillins | 139 |
Copyright | |
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abscess activity acute salpingitis administration adnexal aminoglycoside amniotic fluid ampicillin anaerobic bacteria anaerobic infections anaerobic organisms anti antibacterial antibiotic antibiotic prophylaxis antibiotic therapy Antimicrob Agents Chemother antimicrobial antimicrobial agents antimicrobial therapy asymptomatic bacteremia bacteriuria Bacteroides fragilis Bacteroides species beta-lactamases carbenicillin cefamandole cefazolin cefoxitin cephaloridine cephalosporins cephalothin cephamycin cervical cesarean section chloramphenicol clindamycin clinical Clostridium coli developed diagnosis dosage drug effective efficacy endometritis endomyometritis enterococci evaluation febrile morbidity fetal flora genital tract gentamicin gonococcal gonorrhea gram Gram-negative Gram-positive gynecologic hospital infectious morbidity inhibited intravenous isolated Ledger WJ metronidazole microorganisms nonpregnant Obstet Gynecol oral pathogens pelvic infections penicillin pharmacokinetics placebo plasma polymicrobial post-cesarean postoperative postpartum pregnancy pregnant women prophylactic antibiotics prophylaxis pseudomembranous colitis pyelonephritis regimen renal reported resistant salpingitis sensitive sepsis septic abortion serum levels spectrum studies surgery surgical susceptible tetracycline therapeutic tissue toxicity treatment urinary tract infections urine vaginal hysterectomy vancomycin vitro µg/ml