Anticancer Agents: Frontiers in Cancer Chemotherapy, Volume 796
Iwao Ojima, Gregory D. Vite, Karl-Heinz Altmann, American Chemical Society. Division of Organic Chemistry, American Chemical Society. Division of Medicinal Chemistry, American Chemical Society. Meeting
American Chemical Society, 2001 - Medical - 364 pages
Describes cutting edge approaches in the development of anticancer agents for chemotherapy. These new and interdisciplinary approaches are aimed at the development of tumor specific anticancer agents while increasing the potency against drug-resistant tumors. The volume includes an overview of new paradigms for cancer drug discovery and development by NCI, new generation cytotoxic agents, mechanism based enzyme inhibitors as anticancer agents, anti-angiogenesis agents, antitumor vaccines, and tumor activated prodrugs using immunoconjugates of monoclonal antibodies with cytotoxic agents.
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Evolutionary Biosynthesis of Anticancer Drugs
Some Recent Developments in the Synthesis and Structure
New Generation Taxoids and Hybrids of MicrotubleStabilizing
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3-pyridyl H acid American Chemical Society amino analogs Angew antibody anticancer agents anticancer drugs antigen antitumor activity assay Aziridine binding Biol biological activity bond bryostatin cancer cancer cell lines Cancer Res carcinoma Chem Chemistry clinical trials compounds concentrations conjugate cryptophycin 52 cyclopropane cytotoxic Danishefsky derived discodermolide docetaxel dolastatin dose effects efficacy EGFR enzyme epothilone epoxide ester evaluation farnesyl Figure Fragment FTIs glycoside growth Horwitz human cancer inhibition interaction lactam macrocyclic maytansine methyl mg/kg mice microtubules modifications moiety molecular molecule murine natural product Nicolaou Ojima olefin paclitaxel Pettit pharmacokinetic phase phenyl preclinical prodrug protein reaction receptor Research residues resistant ring sarcodictyins Scheme selectivity semisynthesis side chain spongistatin studies substituent substrate synthetic target taxanes taxoids Taxol therapeutic total synthesis treatment tubulin tubulin polymerization tumor cells tumor models tyrosine kinase VEGF VEGFR-2 vitro vivo xenograft yield