Antiepileptic Drugs: A Clinician's Manual

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Oxford University Press, 2009 - Medical - 250 pages
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Part of the Oxford American Neurology Library, this concise handbook provides practical, up-to-date clinical guidance on effectively selecting, prescribing and monitoring antiepileptic drugs (AEDs), based on drug pharmacokinetics, drug interactions, other uses of AEDs, adverse-effects of AEDs and patient clinical characteristics (i.e. age, comorbidities, and comedications) in partial and generalized epilepsies. This book is designed to provide physicians with a highly patient-focused reference. It provides comprehensive coverage of current treatment options, and in addition to a brief formal discussion of the basic pharmacology of each antiepileptic drug, the text also discusses how to choose pharmacotherapies depending upon underlying medical conditions and the type of epilepsy. The advantages and disadvantages of various drug therapies are reviewed and clear guidance is given as to which drugs should be used in various medical conditions.
The book takes a unique approach by systematically addressing optimum treatment approaches by according to patients' particular medical conditions or comorbidities and other special circumstances, such as how to use and monitor antiepileptic drugs in pregnancy, in the elderly, in the immunosuppressed, etc. It also describes how to correctly prescribe and titrate drugs, how to monitor efficacy and side effects, how to diagnose and manage toxicity, interactions with other drugs, pharmacokinetic properties of AEDs, and other relevant issues for clinicians. This book is an indispensable reference to optimize efficacy and ensuring safety of antiepileptic drug therapies across the patient spectrum.
 

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Contents

1 Diagnosis and Evaluation of Patients With Seizures
2 Antiepileptic Drug Dosage Forms and Administration Guidelines
3 Mechanisms of Action and Pharmacokinetic Properties of Antiepileptic Drugs
4 Monitoring Antiepileptic Drugs and Their Toxicity
5 Choices of Antiepileptic Drugs Based on Specific Epilepsy Syndromes and Seizure Types
6 Clinically Important Drug Interactions With Antiepileptic Drugs
7 Aggravation of Seizures by Antiepileptic Drugs
8 Polytherapy With Antiepileptic Drugs
18 Antiepileptic Drugs in Patients With Hematological Disorders
19 Antiepileptic Drugs in Patients on Chemotherapy or Immunosuppressive Therapy
20 Antiepileptic Drugs in Patients With Stroke
21 Antiepileptic Drugs in Patients With Preexisting Psychiatric Problems or Learning Disabilities
22 Antiepileptic Drugs and Cognition
23 Antiepileptic Drugs in Patients With Migraine Headaches
24 Antiepileptic Drugs in Patients With Neuropathic Pain Syndromes
25 Antiepileptic Drugs in Patients With History of DrugInduced Cutaneous Eruptions

9 Antiepileptic Drugs in Pregnancy
10 Antiepileptic Drugs in Lactating Women
11 Antiepileptic Drugs in the Elderly
12 Antiepileptic Drugs in Patients With Renal Disease
13 Antiepileptic Drugs in Patients With Liver Disease
14 Antiepileptic Drugs and Metabolic Disorders
15 Antiepileptic Drugs in Patients With Hyperlipidemia
16 Antiepileptic Drugs in Patients With Diabetes Mellitus
17 Antiepileptic Drugs in Patients With Cardiovascular Disorders
26 Antiepileptic Drugs and Skin Photosensitivity
27 Antiepileptic Drugs and Ophthalmologic Problems
28 Antiepileptic Drugs and Weight Change
29 Antiepileptic Drugs and Bone Health
30 Antiepileptic Drugs in Patients With HIV InfectionAIDS
31 New Antiepileptic Drugs in Development
Index
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About the author (2009)

A. Ali Asadi-Pooya, MD, is Epileptology and Clinical Neurophysiology Fellow at the Jefferson Comprehensive Epilepsy Center, Department of Neurology at Thomas Jefferson University, Philadelphia, PA. Michael R. Sperling, MD, is Baldwin Keyes Professor of Neurology and Director, JeffersonComprehensive Epilepsy Center, Department of Neurology at Thomas Jefferson University, Philadelphia, PA.

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