Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies

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Guangshun Wang
CABI, 2010 - Medical - 230 pages
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The purpose of this book is to provide a comprehensive account on current antimicrobial peptide research in two major directions. The first direction delineates the classic path for peptide development, ranging through identification, design, structure and mode of action studies. The second direction describes novel strategies for developing peptide therapeutics based on our knowledge of host defence antimicrobial peptides discovered in living organisms. Part I provides an overview of nomenclature, classification and bioinformatic analysis of antimicrobial peptides from bacteria, plants and animals. Subsequently, lantibiotics from bacteria and cyclotides from plants are presented. Part II discusses database-aided peptide prediction and design methods, synthetic combinatorial libraries and peptide mimetics that expand the conformational space of natural antimicrobial peptides. Part III covers the biophysical and structural characterization of antimicrobial peptides and their complexes. Finally, Part IV focuses on novel strategies for developing peptide-based therapies.
 

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Contents

NATURAL ANTIMICROBIAL PEPTIDES NOMENCLATURE CLASSIFICATION AND INTERESTING TEMPLATES FOR PEPTIDE ENGINEER...
1
EXPANDING THE PEPTIDE SPACE PREDICTION METHODS DESIGN STRATEGIES AND PEPTIDOMIMETICS
72
BIOPHYSICS STRUCTURAL BIOLOGY AND MECHANISM OF ACTION OF ANTIMICROBIAL PEPTIDES
116
NOVEL THERAPEUTIC STRATEGIES TO BOLSTER HOST DEFENCE
169
Index
221
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About the author (2010)

Dr. Guangshun Wang, trained as a chemist in China at Yangzhou University and the Chinese Academy of Sciences, obtained his Ph.D. in Biophysical Chemistry from Simon Fraser University, Canada in 1997. He then did his postdoctoral stints at the Florida State University and at the National Institutes of Health, USA with a focus on structural biology of signal-transducing protein-protein complexes by NMR spectroscopy. In 2002, he joined the faculty of the University of Nebraska Medical Center (Omaha, USA). His research interests include structural, bioinformatic, and functional studies of host defense antimicrobial peptides (http://aps.unmc.edu/AP/main.html) and their potential applications that benefit human beings. Dr. Wang has published more than 50 original papers, review articles, and book chapters. He has one US patent granted and two pending. He currently serves as an editor for the Open Journal of Magnetic Resonance and sits on the editorial board of several other journals.

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