Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies
CABI, 2010 - Medical - 230 pages
The purpose of this book is to provide a comprehensive account on current antimicrobial peptide research in two major directions. The first direction delineates the classic path for peptide development, ranging through identification, design, structure and mode of action studies. The second direction describes novel strategies for developing peptide therapeutics based on our knowledge of host defence antimicrobial peptides discovered in living organisms. Part I provides an overview of nomenclature, classification and bioinformatic analysis of antimicrobial peptides from bacteria, plants and animals. Subsequently, lantibiotics from bacteria and cyclotides from plants are presented. Part II discusses database-aided peptide prediction and design methods, synthetic combinatorial libraries and peptide mimetics that expand the conformational space of natural antimicrobial peptides. Part III covers the biophysical and structural characterization of antimicrobial peptides and their complexes. Finally, Part IV focuses on novel strategies for developing peptide-based therapies.
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EXPANDING THE PEPTIDE SPACE PREDICTION METHODS DESIGN STRATEGIES AND PEPTIDOMIMETICS
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Agents and Chemotherapy amino acid amphipathic AMPs anionic lipids anti antibacterial antibacterial activity antibacterial peptides antifungal antimicrobial activity Antimicrobial Agents antimicrobial peptides aureus backbone bacterial membranes bacteriocins binding Biochemistry Biochimica et Biophysica Biological Chemistry Biophysica Acta buforin cathelicidin cationic antimicrobial cells charge chemical clinical combinatorial Craik cyclic cyclotides cysteine cystine knot database defensins disulfide bonds DnaK drugs effects Epand Escherichia coli expression function gene Gram-negative Gram-positive Hancock HDPs helical high-throughput screening hydrophobic immune responses Immunology indolicidin infection inhibit innate immune interactions Journal of Biological kalata B1 lacticin lantibiotic magainin mechanism of action micelles microbial Microbiology mode of action Molecular molecules motif N-terminal neutrophils nisin novel Nucleic Acids outer membrane pathogens plant polypeptide potential properties protease protein receptor Research residues role Sahl selectivity sequence side chains specific strategies structure studies synthesis synthetic target therapeutic toxicity vitamin vitamin D vitro vivo Wang