John Wiley & Sons, Dec 27, 2012 - Science - 270 pages
In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers.
The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
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AAMPs ability ACPs alpha-helical amino acid amphibian amphipathic amphiphilicity AMPs amyloid anionic antibacterial antibiotics anticancer action antifungal antimicrobial activity Antimicrobial Agents antimicrobial mechanisms antimicrobial peptides arginine aurein B-defensins bacteria bacterial membrane beta-defensin bilayer binding Biochemistry Biochimica et Biophysica Biological Chemistry Biology Biomembranes Biophysica Acta Biophysical Journal CAMPs cancer cells cathelicidin cationic antimicrobial peptides Chapter characterization Chemotherapy Craik cyclotides daptomycin database datasets defensins Dennison dermaseptin Drug eukaryotic function fungal fungi gene Gram-negative Gram-negative bacteria Gram-positive Harris helical host defense peptides human hydrophilic hydrophobic immune system Immunology infections innate immune innate immune system Journal of Antimicrobial Journal of Biological lipid magainin mammalian melittin membrane interaction Microbiology Molecular Life Sciences molecules non-cancerous cells novel or-ACPs or-CAMPs or-helices pathogens Peptide Science permeabilization Phoenix phospholipid potential prediction protein q-ACPs q-CAMPs q-helices receptors Research Reviews role sequence shown side-chains structure studies suggested surface target therapeutic therapy toroidal pore translocation Wang