Antioxidants and Cardiovascular Disease

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Jean-Claude Tardif, Martial G. Bourassa
Springer Science & Business Media, 2000 - Medical - 258 pages
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This work addresses a complex problem in cardiovascular medicine. It is written by experts in the fields of atherosclerosis, heart failure, and antioxidants. It should be of interest not only to academicians but also to practising physicians, including postdoctoral fellows, internists, cardiologists, and general practitioners. The first three chapters review the antioxidant hypothesis and its close relationship to lipid mechanisms of action and classify the different and heterogeneous pharmacological compounds with known antioxidant properties, and describe the role of dietary nutrients and supplements as well as the potential therapeutic benefit of antioxidants in coronary artery disease prevention and risk reduction, prevention of endothelial dysfunction, and prevention of chronic heart failure. Finally, current knowledge of the use of these compounds in cardiovascular medicine is summarized.
 

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Contents

CLINICAL ASPECTS OF LIPOPROTEIN METABOLISM AND OXIDATION
1
2 PATHOGENESIS OF ATHEROSCLEROSIS
19
3 THE ANTIOXIDANT HYPOTHESIS
47
4 REACTIVE OXYGEN SPECIES AS MEDIATORS OF SIGNAL TRANSDUCTION IN CARDIOVASCULAR DISEASE
57
5 PHARMACEUTICAL COMPOUNDS WITH ANTIOXIDANT ACTIVITY
71
6 NUTRITION AND ANTIOXIDANTS
85
ANIMAL STUDIES
101
HUMAN STUDIES
117
10 A RATIONALE FOR ANTIOXIDANT USE IN CARDIOVASCULAR DISEASE
145
ANIMAL STUDIES
161
12 ANTIOXIDANTS AND RESTENOSIS HUMAN STUDIES
175
13 ROLE OF OXIDATIVE STRESS CYTOKINES AND APOPTOSIS IN MYOCARDIAL DYSFUNCTION
193
14 OXIDATIVE STRESS AND USE OF ANTIOXIDANTS IN PATIENTS WITH CONGESTIVE HEART FAILURE
211
15 USE OF ANTIOXIDANTS IN CARDIOVASCULAR MEDICINE
225
UPDATE ON RECENTLY COMPLETED CLINICAL TRIALS ON ANTIOXIDANTS AND CARDIOVASCULAR DISEASES
239
Index
245

EVIDENCE FROM OBSERVATIONAL EPIDEMIOLOGIC STUDIES AND RANDOMIZED TRIALS
135

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