Antisense Drug Technology: Principles: Strategies, and Applications

Front Cover
Stanley T. Crooke
CRC Press, Sep 14, 2001 - Medical - 948 pages
0 Reviews
This state-of-the-art reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells as well as those involved in infectious, inflammatory, and immune-mediated diseases-highlighting new tools and technologies in medicinal chemistry, RNA biochemistry, and molecular and cellular biology to produce new therapeutic compounds.
Presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes!

Showcasing the benefits of antisense drug use, including reduced toxicity and earlier disease detection, Antisense Drug Technology discusses
  • novel formulations of antisense drugs
  • practical methods to design effective isotype selective inhibitors
  • molecular mechanisms of antisense drugs
  • mRNA as a current biological template
  • modern postreceptor binding mechanisms
  • and more!
    With contributions by over 60 seasoned experts in the field and containing more than 3000 helpful references, tables, drawings, and photographs, Antisense Drug Technology is an illuminating source for organic, medicinal, and pharmaceutical chemists; biochemists; geneticists; hematologists; oncologists; molecular and cell biologists; virologists; immunologists; and medical school and graduate students in these disciplines.

  •  

    What people are saying - Write a review

    We haven't found any reviews in the usual places.

    Contents

    Basic Principles of Antisense Technology
    1
    Medicinal Chemistry of Antisense Oligonucleotides
    29
    Analytical Methods for Antisense Drugs
    57
    A Role for Antisense Technology in the Discovery of Highly Specific and Versatile Signal Transduction Inhibitors
    83
    Methods of Selecting Sites in RNA for Antisense Targeting
    107
    Pharmacokinetic Properties in Animals
    119
    Suborgan Pharmacokinetics
    155
    Pharmacokinetic Properties in Humans
    183
    PremRNA Splicing as a Target for Antisense Oligonucleotides
    517
    Application of Antisense Oligonucleotides to the Study of CNS Protein Function
    541
    Antisense Approach to IsoformSpecific Blockade of Acetylcholinesterase
    565
    SerineThreonine Protein Phosphatases
    587
    Pharmacological Activities of Antisense Drugs Inflammatory Diseases
    615
    Respirable Antisense Oligonucleotides RASONs
    679
    Combined Antisense Therapy and Chemotherapy in Animal Models
    687
    Antisense Oligodesoxynucleotide Strategies in Renal and Cardiovascular Disease
    709

    Toxicity of Antisense Oligonucleotides
    201
    Clinical Safety of Phosphorothioate Oligodeoxynucleotides
    269
    General Pharmacology of Phosphorothioate Oligodeoxynucleotides
    291
    Pharmacology of 202Methoxyethyl Modified Antisense Oligonucleotides
    319
    LNA Locked Nucleic Acid
    339
    Antisense Properties of Peptide Nucleic Acid PNA
    359
    Phosphorodiamidate Morpholino Oligomers
    375
    Oligonucleotide Conjugates in Antisense Technology
    391
    Immune Stimulation by Oligonucleotides
    471
    The Development of Antisense Oligonucleotides as Antivirals
    725
    Clinical Activities in Patients with Solid Tumors or Lymphoma
    739
    Nucleic Acid Therapeutics for the Treatment of Human Leukemia
    761
    ISIS 2302 an Antisense Inhibitor of Intercellular Adhesion Molecule 1 ICAM1
    773
    New Routes and Novel Formulations for Delivery of Antisense Oligonucleotides
    795
    DNABinding Molecules
    833
    Targeted Genome Modification via Triple Helix Formation
    859
    Intracellular Ribozyme Applications
    887
    Copyright

    Other editions - View all

    Common terms and phrases

    References to this book

    All Book Search results »

    Bibliographic information