Professional Communications, 2004 - Medical - 400 pages
Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice are reviewed.
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Role of Clotting Factors
Antithrombotic Inhibitors Direct Thrombin
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Abbreviations abciximab acute coronary syndrome acute myocardial infarction administration alteplase angioplasty Ann Intern antibodies anticoagulant therapy antiplatelet therapy antithrombotic therapy aPTT aspirin atrial fibrillation benefit binding bivalirudin blood bolus Circulation clinical trials clopidogrel clotting coagulation coronary artery direct thrombin inhibitor dose drug effect embolism Engl enoxaparin eptifibatide fibrin fibrinogen fibrinolytic fibrinolytic therapy Figure fondaparinux glycoprotein IIb/IIIa GPIIb/IIIa GPIIb/IIIa receptor antagonists Group hemorrhage heparin high-risk Investigators ischemia JAm Coll Cardiol Lancet LMWH low molecular weight mg bid mg daily molecular weight heparin mutation nonfatal occlusion oral anticoagulant patency percutaneous coronary intervention placebo plasma plasminogen activator platelet platelet activation platelet aggregation platelet function platelet inhibition prevention protein prothrombin randomised randomized trial recurrent reduced reteplase revascularization risk factors stent streptokinase subcutaneous surgery TABLE Thromb Haemost Thrombolysis thrombotic ticlopidine tients TIMI tion tirofiban tissue treatment unfractionated heparin unstable angina vascular disease venous thromboembolism warfarin ximelagatran