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H Influence of Clinically Determined Drug Resistance on Management
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5-fluorouracil accumulation acid actinomycin activity adenosine adriamycin alkaloids alkylating agents analogs antigens antitumor ascites binding Biochem Pharmacol bleomycin Cancer Res carcinoma cell cycle cell lines cellular chemotherapy Chinese hamster cells chromosome clinical clones compartment concentration cross-links cross-resistance cultured cyclic AMP cyclophosphamide cytotoxic decreased DNA synthesis dose doxorubicin Drewinko drug resistance effects Ehrlich ascites enzyme experimental exposure FUra gene Genet growth HGPRT host HPRT human hybrids immune immunogenicity increased induced infiltration inhibition inhibitors interaction kinase kinetics leukemia levels liver lymphocytes lymphoma macrophages mammalian cells mechanism of resistance melphalan membrane metabolism methotrexate mice Mihich mouse murine mustard mutants Natl Acad Sci neoplasms nitrosoureas normal nucleotide patients phosphorylation population Proc Natl Acad protein purine pyrimidine receptor repair resistant cells response S-phase sarcoma sensitive and resistant sensitive cells studies sublines substrate therapy tion tissue toxicity transplantation transport treatment tumor cells tumour ug/ml uptake vinblastine vincristine vitro vivo