Ap4a and Other Dinucleoside Polyphosphates
Ap4A and Other Dinucleoside Polyphosphates is the first compilation of contributions from major investigators involved in studying the chemistry and biology of dinucleoside polyphosphates. The book features reviews and original research (including unpublished and anecdotal material) covering the whole area of dinucleoside polyphosphate research from its inception to the present day. Ap4A and Other Dinucleoside Polyphosphates will be a useful reference for biological scientists studying nucleotide metabolism, cell signalling, DNA replication and repair, and cellular response to stress.
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TABLE OF CONTENTS
Ultraviolet Light Absorbance
Interaction with Proteins
Determination of Dinucleoside Polyphosphates
Synthesis of NpN n 3 or 4 In Vitro and In Vivo
Enzymes Cleaving Dinucleoside Polyphosphates
ApN and Proliferative State
Ap4A and DNA Replication
ApN and Environmental Stresses
Synthetic Structural Analogues of Dinucleoside Polyphosphates
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5'-nucleotidase Acad acid activity adenine adenosine adenylate adenylate kinase ADP-ribosylation aminoacyl-tRNA synthetases analogues Ap-A Ap,A Ap,A hydrolase Ap,A phosphorylase Ap,A synthesis Ap,G Ap,N Ap.A Ap3A Ap4A apaH AppppA ApsA Artemia assay Bacteriol binding Biochem Biochemistry Biol Biophys Blanquet Catabolism catalyzed cell cycle cellular cerevisiae Chem chromatography compounds concentration cytosol degradation diadenosine 5',5"-P",P'-tetraphosphate diadenosine tetraphosphate diguanosine nucleotides dinucleoside polyphosphates DNA polymerase DNA synthesis effect embryos enzyme Escherichia coli eukaryotic extracts Figure function gene Gp,G Grummt Guranowski heat shock HPLC hydrolase hydrolysis hydrolyzed increase induced inhibition inhibitors intracellular kinase ksgA levels lupin Lüthje McLennan metabolism molecular molecule mutants Natl Np,N Np,N'ase nucleotides Ogilvie oocytes phosphate phosphodiesterase phosphorylase Physarum polycephalum plasma Plateau platelets poly(ADP-ribose presence purified purine pyrophosphate rat liver reaction receptor role Sillero stimulation stress studies substrate specificity symmetrical tetraphosphatase tetraphosphate Ap,A tissues triphosphate tRNA vitro vivo Xenopus yeast Zamecnik