Apoptosis

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Michael D. Jacobson, Nicola J. McCarthy
Oxford University Press, 2002 - Medical - 321 pages
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Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases. This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps.
 

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Contents

Why be interested in death?
1
Future work
16
the genetic
23
Genetic and molecular analysis of programmed cell death
56
Transcriptional regulation of the reaper gene
63
Drosophila caspases
71
How do the cell death regulators rpr hid and grim induce cell death
74
Inhibition of pathological cell death
81
Xenopus egg extracts
186
Acknowledgements
194
Death signalling by the CD95TNFR family
200
Ligands of the TNF receptor superfamily
209
Regulation of death receptorinduced killing
217
Conclusion
224
PDK1independent mechanisms of Akt activation
242
Viruses and apoptosis
262

consequential cleavage
93
Regulation of apoptosis by the Bcl2 family
136
References
149
recent discoveries on Bc12 family proteins
156
Pandoras Box
161
Heat shock proteins
167
lessons from cellfree systems
176
Inhibition of signal transduction pathways involved in defence
270
Cell death in the nervous system
278
Bcl2 family and mitochondria
288
Conclusions
301
Index
317
Copyright

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About the author (2002)

Michael Jacobson is at Millennium Pharmaceuticals Inc., Cambridge, MA, USA. Nicola McCarthy is at Division of Cardiovascular Medicine, Addenbrookes Hospital, Cambridge, UK.

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