Michael D. Jacobson, Nicola J. McCarthy
Oxford University Press, 2002 - Medical - 321 pages
Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases. This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps.
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Why be interested in death?
Genetic and molecular analysis of programmed cell death
Transcriptional regulation of the reaper gene
How do the cell death regulators rpr hid and grim induce cell death
Inhibition of pathological cell death
Xenopus egg extracts
Death signalling by the CD95TNFR family
Ligands of the TNF receptor superfamily
Regulation of death receptorinduced killing
PDK1independent mechanisms of Akt activation
Viruses and apoptosis
Regulation of apoptosis by the Bcl2 family
recent discoveries on Bc12 family proteins
Heat shock proteins
lessons from cellfree systems
Acad Sci USA anti-apoptotic apoptotic cells baculovirus Bcl-2 family Bcl-2 family proteins Bcl-xL binding biochemical Biol Chem Caenorhabditis elegans cascade caspase activation caspase inhibitor caspase-3 caspases Cell Biol cell corpses cell cycle cell survival cell-free systems cellular cleavage cleaved complex cytochrome cytochrome c release cytokine cytoplasmic cytosol death domain disease downstream Drosophila EMBO encodes engulfment expression FADD function gene genetic granzyme homologue Horvitz human IAPs identified induce apoptosis inhibit interaction intracellular involved ligand mammalian cells mechanism mediated mice mitochondrial Mol Cell molecular molecules mutations N-terminal Natl Acad Sci nematode neurons neurotrophin NF-kB nuclear oligomerization Oncogene overexpression phagocytosis phenotype phosphorylation PI3K pro-apoptotic Proc programmed cell death protease protein kinase regulation release of cytochrome response role sequence signalling pathways specific studies substrates suggesting survival signalling target tissues TNFa translocation tumour tumour necrosis factor viral vitro Wang