Apoptosis: from signaling pathways to therapeutic tools
This volume concerns all aspects of apoptosis from signaling pathways to the therapeutic tools that can be derived from an increasing knowledge about the phenomenon of cell death. Discussed in this volume are cell death and development; Mitochondria as regulators of apoptosis, apoptotic signal transduction pathways inhibitors and activation of apoptosis, receptors as mediators of cell death; apoptosis in human disease, including diabetes, blood diseases, and neurodegenerative and cardiovascular disease, transcriptional and post-transcriptional regulation of apoptosis; chromatin structure and apoptosis; the p53 family; and the cell cycle and cell death. Also discussed are caspases and glutathione.
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Academy of Sciences Address for correspondence analysis anti-apoptotic antibody antioxidant apoptosis apoptosis induced assay binding Biochem Biol Ca2+ calcitriol cancer cells caspase activation caspase-3 cell cycle cell lines cellular Chem cleavage concentration cultured cytochrome cytochrome c release cytokine cytosolic cytotoxicity decrease DNA fragmentation effect epithelial cells exposure expression FIGURE fluorescence function gene human hyperoxia increased incubated induced apoptosis infection inhibition inhibitor interaction intracellular involved Jurkat cells Keywords kinase leukemia levels lung mechanism mediated mice modulation molecular mouse mRNA mutations N.Y. Acad necrosis neuronal neutrophils NF-kB nuclear overexpression PARP pathway peptide phosphorylation potential pro-apoptotic proliferation protein reactive oxygen species receptor redox regulation response role sesamol signaling SP-D stained staurosporine sulindac target Tau proteins tion tissues TNF-a TNFa transcription factor transfected treatment trigger tumor cells viral virus vitro vivo Western blot wild-type XIAP York Academy