Springer, Jan 1, 1998 - Medical - 193 pages
Reviewing actual trends in modern biotechnology, this series aims to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. This volume aims to provide an overview of the late 1990s research on apoptosis, and covers various aspects of the apoptotic death process, from the morphological and biochemical features, mechanisms and genetic regulation to its role in pathological process, and potential implications for biomedical research and biopharmaceutical production.
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Genetic Regulation of Cell Death
Implications for Biomedical and Biopharmaceutical Research
Z Darzynkiewicz F Traganos
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Acad Sci USA amino acids analysis anti-apoptotic apoptosis apoptosis induced apoptotic cells assay bcl-2 family bcl-2 family members bcl-xL BH3 domain binding Biochem Biol Chem c-myc C-terminus Cancer Res caspase-3 caspases Cell Biol cell cycle cell lines cell types cellular ceramide chromatin cleavage cleaved culture cytokines Darzynkiewicz detected Dixit VM DNA content DNA fragmentation DNA strand breaks enzyme expression flow cytometry fluorochrome function gene granzyme growth factor homology hybridoma identified IGF-IR Immunol induced apoptosis induction of apoptosis inhibit inhibitor interact Korsmeyer Korsmeyer SJ levels mammalian mechanism mediated mice mitochondrial mode of cell molecular molecules morphological mutants Natl Acad Sci necrosis necrotic cells neurons neurotrophins NFkB nuclear Oncogene over-expression PARP phosphorylation PI-3 kinase plasma membrane Proc Natl Acad proteases protein receptor Reed JC regulation role serum shown substrate suppression of apoptosis survival factors survival signals tion tissue Traganos transfected undergo apoptosis Wang