Apoptosis: Physiology and Pathology
Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.
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antiapoptotic apop apoptosome apoptotic cell aSMase autophagy Bcl-2 family Bcl-xL beta cell BH3-only proteins binding Biol breast cancer Ca2+ calpain caspase caspase activation caspase-3 caspase-9 cellular ceramide cleavage complex cytochrome cytokines cytosol cytotoxic death receptor degradation diabetes disease DNA damage domain effector elegans enzymes epithelial cells epithelium expression FADD function gene genetic germ cell germ cell apoptosis granules granzyme growth factor hair cells human immune increased induce apoptosis infarct inhibition inhibitor injury interaction involution involved ischemia JBiol Chem kinase ligand lung lymphocytes lysosomal macrophages mammalian mammary mechanisms mediated membrane metabolic mice mitochondrial molecular molecules mouse muscle mutations necrosis neurons neurotrophins ofthe olfactory over-expression oxidative pathogens perforin phosphorylation proapoptotic programmed cell death protease regulation release response role sepsis signaling sphingolipid stress studies substrates target teins tion tissue tosis transcription transgenic trigger tumor ubiquitin upregulation vivo XIAP yeast zebrafish