James W. Wilson, Catherine Booth, C. S. Potten
Springer Science & Business Media, 1998 - Medical - 310 pages
Apoptosis, or programmed cell death, is a natural process by which damaged or unwanted cells are dismantled in an orderly and atraumatic fashion. It is of critical importance in development, homeostasis, and cell population control. Research over the last decade is now enabling scientists to comprehend how genes and the protein products interact to control apoptosis. This has led to the current position where researchers may be able to directly modify the action of key proteins through gene therapy and antisense oligonucleotides.
Apoptosis Genes presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. While there are several books written on apoptosis, Apoptosis Genes deals specifically with the regulation of apoptosis. Given the increased interest in the role of apoptosis genes in disease processes, this work will be useful to researchers investigating cancer, autoimmune disease, viral infection, cardiovascular disease, neurodegenerative disorders, AIDS, osteoporosis, and aging.
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Acad adenovirus apoptosis induced apoptotic baculovirus Bcl-2 family members Bcl-2 homologues Bcl-xL BH3 domain c-Myc Caenorhabditis elegans Cancer Res caspase-1 caspases Cell Biol cell cycle cell growth cell line cell types cellular Chem cleavage cloned cyclin cytokines cytoplasmic cytotoxic death pathway defective DNA binding DNA damage Drosophila dying cells effector EMBO embryos encodes epithelial etal fibroblasts focal adhesion gene expression genetic growth arrest growth factor homologues Horvitz human induce apoptosis induction of apoptosis infection inhibit inhibitor integrins interaction intracellular ionising radiation irradiation lymphoma mammalian mechanism mediated membrane mice mitochondrial modulate molecular mutant Natl neurons NF-kB Oncogene overexpression p53 protein p53-dependent apoptosis phosphorylation pro-apoptotic Proc programmed cell death promoter protease protein kinase reaper receptor regulation response role sequence signal transduction signalling pathways Sindbis virus specific suggesting suppress apoptosis tissues transactivation transcription factor transcriptional activation transfected tumour cells viral Virol vitro vivo wild type
Page 238 - Kerr, JFR, Wyllie, AH, and Currie, AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.