Apoptosis in Health and Disease
Robert R. Ruffolo, Jr., Frank Walsh
CRC Press, Sep 2, 2003 - Science - 368 pages
The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation and organ remodelling. It is hoped that, with an increase in our understanding of the mechanisms controlling apoptosis, there will come the development of a new class of drugs which can pharmacologically manipulate apoptosis and thus provide a means to treat important diseases which currently pose problems to our society.
Containing papers presented at the Eleventh SmithKline Beecham Pharmaceuticals United States Research Symposium and with contributions from leading researchers, Apoptosis in Health and Disease offers a comprehensive review of important developments and research in the field.
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Acad angioplasty anti-apoptotic antibodies apoptosis apoptotic apoptotic cells artery atherosclerotic Bcl-2 family Bcl-xL biochemical Biol cardiac cardiomyocytes cascade caspase caspase activation caspase inhibitors caspase-3 cathepsin D cell cycle cellular cerebral ischemia Chem Cheng cleavage cleaved cysteine protease cytochrome cytosol DAP-kinase death pathways disease DNA damage DNA fragmentation domain drug elegans enzyme expression Figure function gene genetic Hamet homologues human hypertension hypoxia hypoxic increased inhibition injury integrin interactions interleukin-1 intima intimal mass ischemic kinase lesions losartan lumen MacManus mammalian mechanisms mediated membrane mice mitochondrial molecular mRNA mutant myocytes necrosis neuronal death neurons Neurosci nifedipine nuclear overexpression oxidative patients pro-apoptotic programmed cell death proliferation prostate cancer protease protein receptor regulation remodeling reoxygenation reperfusion replication role Saikumar Schwartz signaling Sindbis virus SMC apoptosis smooth muscle cells specific stimuli studies suggest sympathetic neurons target Thornberry thymocytes transfected tumor vessels vitro vivo Wang yeast