Apoptosis in Health and Disease: Clinical and Therapeutic Aspects
Martin Holcik, Eric C. LaCasse, Alex E. MacKenzie, Robert G. Korneluk
Cambridge University Press, Feb 17, 2005 - Medical - 249 pages
The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states.
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Acad Alzheimer's disease amyotrophic lateral sclerosis anti-apoptotic antisense apop apoptosis-inducing apoptotic apoptotic cells autoimmune autophagy Bcl-2 family Bcl-XL beta cells cardiac cardiomyocyte cardiomyocyte apoptosis caspase caspase activation caspase inhibitors caspase-3 CD8+ T cells Cell Biol cellular Chem cleavage cytochrome cytokines cytoplasmic cytotoxicity death receptors degeneration diabetes DNA damage Drosophila effector elegans excitotoxic expression factor Fas ligand function gene genetic genome granzyme human IAPs Immunol induces apoptosis infarction inhibition inhibitor of apoptosis interaction intracellular involved kinase ligand lymphocytes Martin mechanisms mediated membrane mitochondrial molecular molecules mouse mutations myocardial myocyte Natl neurodegeneration neurons Neurosci NF-kB NOD mice perforin phosphorylation pro-apoptotic Proc programmed cell death protease protein regulation reperfusion role signaling pathways smooth muscle cells survival therapeutic therapy tissue transgenic mice translocation trigger tumor cells tumor necrosis vascular smooth muscle virus vitro vivo VSMC apoptosis Wang XIAP
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