Apoptosis and Inflammation

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James Winkler
Springer Science & Business Media, Jul 1, 1999 - Medical - 244 pages
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Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. However, many disease conditions utilize apoptosis for pathological ends, resulting in inappropriate cell death and tissue destruction. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases.
 

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Contents

Floyd H Chilton III Floyd H Chilton Jr Carl E Clay Anthony Trimboli
19
John H Russell
39
John Savill and Christopher Haslett
53
Don J Park and Mark J Koury
85
Martin Lotz Sanshiro Hashimoto Robert Ochs and Klaus Kuhn
101
David A Norris Yiqun Shellman and Gary A Bellus
121
Paul P Tak and Gary S Firestein
149
Mark E Nuttall Maxine Gowen and Michael W Lark
163
Gwan Gyu Song Martin Fleck Jianguo Wu HuiChen Hsu Tong Zhou
181
Curtis A Raskin
213
Victoria Y Wong Shujath M Ali and David P Brooks
227
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Page 234 - S. (1991) The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66.

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