Apoptosis in Neurobiology
Yusuf A. Hannun, Rose-Mary Boustany
CRC Press, Dec 24, 1998 - Science - 296 pages
The rapid growth of the study of apoptosis-mechanism-driven, regulated cell death-has created an urgent need for reliable documentation of the different approaches to and methods of studying the various aspects of the field. Apoptosis in Neurobiology is an important resource for researchers in this emerging frontier of biomedical study. This volume allows the uninitiated neuroscientist intellectual and practical access to the study of apoptosis, with special consideration to the nervous system. The first section concentrates on conceptual approaches to the study of apoptosis in neurobiology and its significance to the nervous system. The second section provides a user-friendly approach to methods and techniques in the study of apoptosis as applied to neurobiology.
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Acad acid Alzheimer's disease antiapoptotic antibody apoptosis apoptotic cell death assay astrocytes Batten disease Biochem Biol Chem brain buffer Cancer Res caspase activation caspase-3 caspases Cell Biol cell lines cellular ceramide chromatin cleavage cleaved culture cysteine protease cytochrome cytoplasm cytosol demonstrated detection DNA fragmentation elegans enzyme excitotoxic expression fixation flow cytometry fluorescence function genetic genome glial Hannun human incubation induce apoptosis infection inhibition inhibitors injury involved labeling lamin levels lipid mammalian mechanisms mediated membrane method mitochondrial molecular morphological motoneurons mutations Natl nervous system neuroblastoma neurodegenerative diseases neuronal apoptosis neuronal cell neuronal death Neurosci neurotrophin NF-KB normal nuclear nuclei overexpression Parkinson's disease pathways polypeptide potential Proc production programmed cell death protein kinase receptor regulation role samples signal SMase specific sphingomyelin spinal studies substrate target tissue transgene transgenic mice trophic tumor necrosis TUNEL staining vector virus vitro vivo Wang