Apoptosis in Toxicology
R. J. Roberts
CRC Press, Apr 12, 2002 - Medical - 248 pages
Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the initiator and executioner caspases.
Emphasis is given to the role apoptosis plays in the action of toxicants in the brain, the immune system, the reproductive organs, the kidney and the liver. The ability of drugs to regulate apoptosis either as a target or as an adverse effect is discussed with particular reference to cancer chemotherapy. The many methods that can be employed to quantify apoptosis are compared and their application to different tissues is discussed.
This timely and comprehensive volume has been written by leading authorities and active researchers in their respective fields. It will have broad appeal to toxicologists, physicians and biologists across many disciplines.
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Academy of Sciences acid anti-apoptotic antibodies apoptosis apoptosis induced Applied Pharmacology Bcl-2 family members Bcl-XL Biochemical Biological Chemistry Cancer Research Carcinogenesis carcinogens caspase caspase activation caspase-1 caspase-3 cell apoptosis Cell Biology cell lines cell survival cell types cellular ceramide cytochrome cytokine cytotoxic disease DNA damage effects Endocrinology enzyme etal Experimental Fas ligand follicles function germ cell growth factor hepatic hepatocytes human increase induce apoptosis induction of apoptosis inhibition intracellular Journal of Biological Journal of Immunology kidney KORSMEYER lethality levels Leydig cells ligand liver injury mechanism membrane mitochondrial Molecular mouse murine mutations National Academy neuronal nongenotoxic carcinogens oocyte ovarian ovary overexpression oxidative damage oxidative stress pathways peroxisome peroxisome proliferator protease protect protein kinase renal Reproduction response reviewed role Sertoli cells signalling spermatocytes synthesis TCDD testicular testis TILLY tissue TNF receptor toxicants Toxicology and Applied toxins transcription tumor necrosis factor vitro vivo WANG wild-type Woolveridge