Applications And Engineering Of Monoclonal Antibodies
A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and a case study approach illustrates how antibodies are finding increasing use in the diagnosis and treatment of disease. The volume ends with commercial expression, purification and large-scale manufacture of antibodies and their future potential, particularly as therapeutic agents.
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1 Preparation Structure and Function of Monoclonal Antibodies
Design for Specific Applications
3 Monoclonal Antibodies in Research and Diagnostic Applications
4 Monoclonal Antibodies in Therapeutic Applications
5 Production of Monoclonal Antibodies
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achieved activity allow anti-tumour antibody fragments antibody molecules antigen antigen-binding applications assay attachment binding bispecific antibody blood Cancer Res cell lines chelator Chem chemically cross-linked chimeric antibodies chromatography clinical coli colorectal conjugates constant region cytokines cytotoxic detection developed diabodies disease disulphide bonds dose drug effector functions effects engineered enzyme epitope expression F(ab 2 fragments Fab fragments Fc receptor fluorescent fusion proteins half-life heavy and light heavy chain hinge region human antibodies humanised hybridoma IgG1 IgG4 imaging immobilised immune response immunoaffinity chromatography immunoassay immunogenicity immunoglobulin Immunol immunotoxins improved interaction isotypes labelled light chain linkers MAbs method mice monoclonal antibody mouse murine antibody Natl Acad Nucl patients peptide phage display pharmacokinetics Proc produced purification radioimmunodetection radioimmunotherapy radiolabelled reagents recombinant antibody residues scFv sequence specific structure studies targeting techniques therapeutic therapy thiol tissue toxicity toxin tumour tumour cells variable domains variable region vitro vivo