Applications And Engineering Of Monoclonal Antibodies

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CRC Press, Nov 27, 1998 - Medical - 249 pages
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A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and a case study approach illustrates how antibodies are finding increasing use in the diagnosis and treatment of disease. The volume ends with commercial expression, purification and large-scale manufacture of antibodies and their future potential, particularly as therapeutic agents.
 

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Contents

1 Preparation Structure and Function of Monoclonal Antibodies
1
Design for Specific Applications
26
3 Monoclonal Antibodies in Research and Diagnostic Applications
72
4 Monoclonal Antibodies in Therapeutic Applications
112
5 Production of Monoclonal Antibodies
151
6 Prospects for Engineered Antibodies in Biotechnology
175
7 References
181
Index
225
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