Applications of Antisense Therapies to Restenosis

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LeRoy E. Rabbani
Springer Science & Business Media, Feb 28, 1999 - Medical - 184 pages
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Restenosis, the proliferation of smooth muscle cells (SMC) that line blood vessels, often follows angioplasty. Despite advances in cardiology, restenosis continues to affect up to 40% of the over 500,000 patients who undergo angioplasty each year.
Applications of Antisense Therapies to Restenosis is the first volume to address the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting. The work critically examines the application of various antisense therapies for inhibiting restenosis.
 

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Contents

RESTENOSIS THE CLINICAL PROBLEM
1
THE PATHOBIOLOGY OF RESTENOSIS A PARADIGM FROM CLINICAL AND EXPERIMENTAL STUDIES
21
CORONARY REPAIR AND RESTENOSIS CELLULAR BASIS FOR ANTISENSE APPROACHES
35
VASCULAR SMOOTH MUSCLE CELL BIOLOGY AND RESTENOSIS
45
VASCULAR ANTISENSE THERAPY DIRECTED AGAINST cmyc cmyb and PCNA
71
PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES AS INHIBITORS OF GENE EXPRESSION ANTISENSE AND NONANTISENSE EFFECTS
99
MOLECULAR THERAPIES FOR VASCULAR DISEASE ALTERING THE BALANCE BETWEEN CELL GROWTH AND CELL DEATH
119
OLIGONUCLEOTIDES CONTAINING THE GQUARTET SEQUENCE MOTIF
133
NONGQUARTET NON SEQUENCE SPECIFIC ANTIRESTENOTIC EFFECTS OF PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES
141
LOCAL DELIVERY OF ANTIRESTENOTIC DRUGS
153
CRITICAL CONSIDERATIONS AND FUTURE DIRECTIONS
163
Index
181
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