Applications of Nuclear Microprobe in the Life Sciences: An Efficient Analytical Technique for the Research in Biology and Medicine
This book describes the capabilities of nuclear techniques for elemental microanalysis in the biological field. A description of basic principles is given at the beginning, with special emphasis on X-ray Fluorescence, Rutherford Backscattering Spectrometry, Nuclear Reaction Analysis and Scanning Transmission Ion Microscopy. The major part of the volume is devoted to the applications in the life sciences and presents a general review of the subjects investigated during the last fifteen years. In addition, technical aspects of nuclear microanalysis in living tissues, including data processing and specimen preparation, are detailed. Examples of recent applications in cellular pharmacology, cell physiology and biomedicine are presented. The last part concerns the studies of unicellular micro-organisms involved in pollution problems. Postgraduate students and confirmed scientists will be able to find here basic information, references and practical aspects of this new tool, with in each case a comparison with other analytical techniques.
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Concepts and Principles
Equipment and Techniques
Application to Pharmacology
Application to Physiology
Application to Pathology and Clinic
Application to Trace Elements and Toxicology
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accumulation aluminium Alzheimer's disease andMeth anthracycline applications arteries atomic biological biological tissue blood cells Ca2+ calcium Cancer cell line cellular Cholewa cisplatin concentration cooling copper cross-section cryofixation cryosections culture damage density detection detector disease distribution drug effect electron microscopy elemental maps embedding energy experimental fluorescence freeze-drying hair human implant increase induced intracellular investigated ion beam ion beam analysis ionisation iron irradiation kind permission laser layer Legge Lindh Llabador magnesium Malmqvist mass spectrometry membrane mercury Meth MeV proton beam micro-PIXE microbeam microprobe analysis molecular Moretto neuroblastoma Nucl Instr nuclear microanalysis nuclear microprobe observed obtained p-cells Pallon Palsgard particles phosphorus plaques plasma platinum proteins proton proton microprobe quantitative ratio rats region sample scanning sections selenium sensitivity spatial resolution specimen STIM surface synchrotron radiation taurine technique temperature Themner thickness tissue titanium toxic trace elements trace metals tumor vitro Watt X-ray fluorescence X-ray microanalysis zinc