Applied Molecular Genetics of Filamentous Fungi
J.R. Kinghorn, Geoffrey Turner
Springer Science & Business Media, Aug 31, 1992 - Medical - 259 pages
The filamentous fungi are perhaps unique in the diversity of their metabolic activities. This includes biosynthetic as well as degradative activities, many is to provide an of which are of industrial interest. The objective of this text up-to-date and broad review which emphasizes the genetic and molecular biological contribution in the field of fungal biotechnology. This text begins with an overview of the tools and methodologies involved which, to a large extent, have been developed in the model filamentous fungus Aspergillus nidulans and subsequently have been extended to commercially important fungi. This is followed by a chapter which provides a compilation of genes isolated from commercial fungi and their present status with respect to structure, function and regulation. Chapters 3 and 4 highlight the degradative powers of filamentous fungi. First, a discussion of what is known regarding the molecular genetics of fungi and the genes and enzymes involved in the beverage and food industries. This has an oriental flavour, reflecting the tremendous importance of fungi in traditional Chinese and Japanese food production. An account of lignocellulose degradation by filamentous fungi follows, illustrating the potential of fungi to utilize this substance as a renewable energy source. The ability of fungi to produce high-value foreign proteins is reviewed in chapters 5 and 6. Chymosin production, in particular, represents a good example of high-level yields being obtained, such as to warrant commercial production.
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a-amylase Acids Res activity Agric amino acid amino acid sequence amy genes amylase analysis antibiotics aspartic protease Aspergillus Aspergillus nidulans awamori bacterial Bacteriol Berka Biochem Biol biological biosynthesis Biotechnol Biotechnology bisporus cDNA Cell cellulose cephalosporin cerevisiae Chem chromosome chrysogenum chrysosporium chymosin cloned containing crassa culture Curr degradation edodes enzyme expression extracellular fermentation Figure filamentous fungi fungal fungus gene encoding Genet genomic glaA glucoamylase glucose growth heterokaryon heterologous homokaryon homologous Hondel host hybridization industrial introns IPNS isolated levels lignin lignin peroxidase lipase manganese peroxidase medium Microbiol miehei molecular mushroom mutants nidulans niger niveus nucleotide organisms oryzae oxidase oxidation pathogenicity pcbAB pcbC penicillin peptide plasmid probe Proc production promoter protease protein protoplasts Pulp purified recombinant reesei region RFLP Rhizopus RNase secondary metabolites secreted selective markers species spores starch strains studies substrate synthase synthetase transcription transformation vector xylanases yeast