Applied Molecular Genetics of Filamentous Fungi

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J.R. Kinghorn, Geoffrey Turner
Springer Science & Business Media, Aug 31, 1992 - Medical - 259 pages
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The filamentous fungi are perhaps unique in the diversity of their metabolic activities. This includes biosynthetic as well as degradative activities, many is to provide an of which are of industrial interest. The objective of this text up-to-date and broad review which emphasizes the genetic and molecular biological contribution in the field of fungal biotechnology. This text begins with an overview of the tools and methodologies involved which, to a large extent, have been developed in the model filamentous fungus Aspergillus nidulans and subsequently have been extended to commercially important fungi. This is followed by a chapter which provides a compilation of genes isolated from commercial fungi and their present status with respect to structure, function and regulation. Chapters 3 and 4 highlight the degradative powers of filamentous fungi. First, a discussion of what is known regarding the molecular genetics of fungi and the genes and enzymes involved in the beverage and food industries. This has an oriental flavour, reflecting the tremendous importance of fungi in traditional Chinese and Japanese food production. An account of lignocellulose degradation by filamentous fungi follows, illustrating the potential of fungi to utilize this substance as a renewable energy source. The ability of fungi to produce high-value foreign proteins is reviewed in chapters 5 and 6. Chymosin production, in particular, represents a good example of high-level yields being obtained, such as to warrant commercial production.
 

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Contents

Fungal technology
1
References
25
References
50
marker
68
Fungal enzymes for lignocellulose degradation
100
References
124
Foreign proteins
132
Stability of recombinant strains under fermentation conditions
152
References
173
References
188
The application of molecular genetics to oriental mushrooms
201
Secondary metabolites
214
References
248
Index
257
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Page viii - Department of Cell Biology, Baylor College of Medicine, 1 Baylor Plaza. Houston. TX 77030 USA.

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About the author (1992)

Geoffrey Turner was the Head of Theology for over twenty years at Trinity and All Saints College, University of Leeds (now Leeds Trinity University College) and is a former President of the Catholic Theological Association of Great Britain.

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