Applying the Evidence: Clinical Trials in Diabetes
Recent large-scale clinical trials have provided a wealth of information regarding the optimal management of diabetes. In this compact volume, Barnett (medicine, Birmingham Heartlands Hospital, UK) summarizes the results of key studies investigating such issues as cardiovascular mortality, erectile dysfunction, and retinopathy. The text is accompan
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Prevention of Diabetes
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ACE inhibitor agents all-cause mortality Analysis Intention angiotensin-II receptor blocker Atorvastatin Authors blood glucose control blood pressure cardiovascular disease cardiovascular events cardiovascular risk clinical Commentary Conventional therapy coronary heart disease cost-effective DAFNE Diabetes Study UKPDS diabetes-related death diabetic patients dose effects fasting plasma glucose fenofibrate Figure glucose tolerance glycaemic control HbAk HbAlc hypertension hypoglycaemia impaired fasting glucose Inhaled insulin insulin glargine Intensive therapy intensive treatment Intention to treat intervention irbesartan Kaplan-Meier LDL cholesterol levels lifestyle lipid lipoprotein Massachusetts Medical Society metformin Methodology Randomised controlled mg/dL microalbuminuria mmol/L myocardial infarction niacin patients with diabetes patients with type placebo primary endpoint Prospective Diabetes Study ramipril Randomised controlled trial Relative risk renal renin-angiotensin system Reproduced with permission retinopathy risk factors risk reduction rosiglitazone Secondary endpoints included Sildenafil Simvastatin statin sulphonylurea Telmisartan tight BP control trandolapril treat Follow-up trial tell triglycerides type 2 diabetes UK Prospective Diabetes Verapamil versus weeks