Elsevier, Apr 4, 2001 - Science - 390 pages
Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems.
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Structure and Function
Chapter 3 Physiological Roles of Aquaporins in the Kidney
Chapter 4 Pathophysiology of Renal Aquaporins
Chapter 5 Genetic and Biophysical Approaches to Study Water Channel Biology
Chapter 6 Trafficking of Native and Mutant Mammalian MIP Proteins
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2D crystals Acad activity Agre amino acid analysis AQP0 AQP1 AQP2 AQP2 expression AQP3 AQP4 AqpZ aquaporin-2 aquaporins basolateral Biol cellular Chem Clin cloning coli collecting duct cytoplasmic cytosolic Deen descending limb Ecelbarger electron electron crystallography encoding Engel epithelial fluid fluorescence Fps1p function gene genome GlpF glycerol facilitator gradient helices homologs increase kinase Knepper knockout mice levels loop lung mammalian Marples Maurel measured medullary collecting duct membrane protein microscopy MIP channels molecular monomer mutant Natl nephrogenic diabetes insipidus Nielsen null mice oocytes Operon osmolality osmotic osmotic water permeability pathway perfused phenotype phosphorylation Physiol physiological plant cells plasma membrane pore projection map proximal tubule rat kidney receptor regulation renal residues role root sequence solute structure studies subfamily surface tetramers tissues tonoplast transfected transmembrane unit cell urinary concentrating urine vacuole vasa recta vasopressin Verkman vesicles volume Walz water channel water transport wild-type Xenopus oocytes xylem yeast