Arterial Chemoreception: From Molecules to Systems
Colin A. Nurse, Constancio Gonzalez, Chris Peers, Nanduri Prabhakar
Springer Science & Business Media, Oct 19, 2012 - Medical - 406 pages
Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid. Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis. Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body. Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases. Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come. It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.
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Chapter 1 The Role of HypoxiaInducible Factors in Oxygen Sensing by the Carotid Body
Chapter 2 Neuronal Mechanisms of Oxygen Chemoreception An Invertebrate Perspective
Chapter 3 Peripheral Chemoreceptors in Air Versus Water Breathers
Chapter 4 SexSpeci ﬁ c Effects of Daily Gavage with a Mixed Progesterone and Glucocorticoid Receptor Antagonist on Hypoxic Ventilatory Respons...
Chapter 5 AgeDependent Changes in Breathing Stability in Rats
Chapter 6 Dose Dependent Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats
Chapter 7 Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization
Chapter 8 Erythropoietin and the SexDimorphic Chemore ﬂ ex Pathway
Chapter 29 Spexin Is Expressed in the Carotid Body and Is Upregulated by Postnatal Hyperoxia Exposure
Chapter 30 Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction Between Hypoxia and Hypercapnia in the Carotid Body
Chapter 31 Interactions Between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respirato...
Chapter 32 BrainDerived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis After Carotid Chemoreceptor Stimulati...
Chapter 33 Hydrogen Sul ﬁ de Acting at the Carotid Body and Elsewhere in the Organism
Chapter 34 Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats
Chapter 35 Serotonin Dynamics and Actions in the Rat Carotid Body Preliminary Findings
Chapter 36 Human Carotid Body HIF and NGB Expression During Human Development and Aging
Chapter 9 TimeCourse of Ventilation Arterial and Pulmonary CO 2 Tension During CO 2 Increase in Humans
Chapter 10 Oxygen Sensitive Synaptic Neurotransmission in AnoxiaTolerant Turtle Cerebrocortex
Chapter 11 Ion Channel Regulation by the LKB1AMPK Signalling Pathway The Key to Carotid Body Activation by Hypoxia and Metabolic Homeos...
Chapter 12 Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices
Chapter 13 Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells
Chapter 14 Acute Hypoxia Does Not In ﬂ uence Intracellular pH in Isolated Rat Carotid Body Type I Cells
Chapter 15 Hydrogen Sul ﬁ de H 2 S A Physiologic Mediator of Carotid Body Response to Hypoxia
Chapter 16 The Retrotrapezoid Nucleus and Breathing
Chapter 17 The Interaction Between Low Glucose and Hypoxia in the in vitro Rat Carotid Body
Chapter 18 Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans?
Chapter 19 Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation
Chapter 20 CO 2 Signaling in Chemosensory Neuroepithelial Cells of the Zebra ﬁ sh Gill Filaments Role of Intracellular Ca 2+ and pH
Chapter 21 Hyperplasia of Pulmonary Neuroepithelial Bodies NEB in Lungs of Prolyl Hydroxylase 1PHD1 De ﬁ cient Mice
Chapter 22 PrecisionCut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal M...
Chapter 23 Oxygen Sensitivity of Gill Neuroepithelial Cells in the AnoxiaTolerant Goldfish
Chapter 24 Interaction of Hypoxia and Core Temperature Potential Role of TRPV1
Chapter 25 Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats
Chapter 26 LPSInduced cFos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats Are Suppressed by Bilateral Carotid Chemod...
Chapter 27 Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells Potential Role of the K ATP Channel
Chapter 28 Contribution of In ﬂ ammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia
Chapter 37 Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia
Chapter 38 ATP Release from the Carotid Bodies of DBA2J and AJ Inbred Mouse Strains
Chapter 39 Effect of Oxygen on Phosphodiesterases PDE 3 and 4 Isoforms and PKA Activity in the Superior Cervical Ganglia
Chapter 40 Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat
Chapter 41 Upregulation of Pituitary Adenylate Cyclase Activating Polypeptide and Its Receptor Expression in the Rat Carotid Body in Chronic and I...
Chapter 42 Rabbit Ventilatory Responses to Peripheral Chemoexcitators Effects of Chronic Hypoxia
Chapter 43 Effect of Chronic Caffeine Intake on Carotid Body Catecholamine Dynamics in Control and Chronically Hypoxic Rats
Chapter 44 Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs Clinical Significance
Chapter 45 Some Re ﬂ ections on Intermittent Hypoxia Does it Constitute the Translational Niche for Carotid Body Chemoreceptor Researchers?
Chapter 46 Role of CentralPeripheral Chemoreceptors and Their Interdependence in the Pathophysiology of Sleep Apnea
Chapter 47 Physiologic Basis for Intermittent Hypoxic Episodes in Preterm Infants
Chapter 48 Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats
Chapter 49 Contribution of TASKLike Potassium Channels to the Enhanced Rat Carotid Body Responsiveness to Hypoxia
Chapter 50 Antioxidation and the Hypoxic Ventilatory Response
Chapter 51 Differential Regulation of Tyrosine Hydroxylase by Continuous and Intermittent Hypoxia
Chapter 52 Heart Failure and Carotid Body Chemoreception
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activity acute hypoxia adult airway AMPK animals anoxia Appl Physiol Arterial Chemoreception Ballanyi baroreflex BDNF Biology 758 blood brainstem breathing C.A. Nurse Ca2+ caffeine carotid body carotid sinus catecholamine chemoreceptor cells chemoreflex chemosensory chromaffin cells chronic hypoxia chronic intermittent hypoxia decrease depolarization effects exposure expression FiO2 function glomus cells glucose Gonzalez hypercapnia hypercapnic hyperoxia hypoxia-induced hypoxia-inducible factor hypoxic increase induced inhibition intracellular K+ channels levels lung mangiferin mechanisms Media Dordrecht 2012 mediated membrane metabolic mice mifepristone mmHg Molecules to Systems NECs neonatal nerve neurons Neurosci normoxia normoxic oxidative oxygen sensing PACAP PaCO2 Peng peripheral chemoreceptors Physiology postnatal potential Prabhakar progesterone protein pulmonary rabbit rat carotid body receptors regulation release Respir Physiol Neurobiol respiratory response to hypoxia role Science+Business Media Dordrecht sensitivity sensory sleep apnea slices Springer Science+Business Media stimulation tissue TRPV1 type I cells ventilation