Arterial Chemoreception: From Molecules to Systems

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Colin A. Nurse, Constancio Gonzalez, Chris Peers, Nanduri Prabhakar
Springer Science & Business Media, Oct 19, 2012 - Medical - 406 pages
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Arterial chemoreceptors are unique structures which continuously monitor changes in arterial blood oxygen, carbon dioxide, glucose, and acid. Alterations in these gases are almost instantaneously sensed by arterial chemoreceptors and relayed into a physiological response which restores blood homeostasis. Arterial Chemoreception contains updated material regarding the physiology of the primary arterial chemoreceptor; the carotid body. Moreover, this book also explores tantalizing evidence regarding the contribution of the aortic bodies, chromaffin cells, lung neuroepithelial bodies, and brainstem areas involved in monitoring changes in blood gases. Furthermore this collection includes data showing the critical importance of these chemoreceptors in the pathophysiology of human disease and possible therapeutic treatments. This book is a required text for any researcher in the field of arterial chemoreception for years to come. It is also a critical text for physicians searching for bench-to-bedside treatments for heart failure, sleep apnea, and pulmonary hypertension.
 

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Contents

Chapter 1 The Role of HypoxiaInducible Factors in Oxygen Sensing by the Carotid Body
1
Chapter 2 Neuronal Mechanisms of Oxygen Chemoreception An Invertebrate Perspective
7
Chapter 3 Peripheral Chemoreceptors in Air Versus Water Breathers
18
Chapter 4 SexSpeci fi c Effects of Daily Gavage with a Mixed Progesterone and Glucocorticoid Receptor Antagonist on Hypoxic Ventilatory Respons...
29
Chapter 5 AgeDependent Changes in Breathing Stability in Rats
37
Chapter 6 Dose Dependent Effect of Progesterone on Hypoxic Ventilatory Response in Newborn Rats
43
Chapter 7 Postnatal Hyperoxia Impairs Acute Oxygen Sensing of Rat Glomus Cells by Reduced Membrane Depolarization
49
Chapter 8 Erythropoietin and the SexDimorphic Chemore fl ex Pathway
55
Chapter 29 Spexin Is Expressed in the Carotid Body and Is Upregulated by Postnatal Hyperoxia Exposure
206
Chapter 30 Cyclic AMP and Epac Contribute to the Genesis of the Positive Interaction Between Hypoxia and Hypercapnia in the Carotid Body
215
Chapter 31 Interactions Between Postnatal Sustained Hypoxia and Intermittent Hypoxia in the Adulthood to Alter Brainstem Structures and Respirato...
224
Chapter 32 BrainDerived Neurotrophic Factor in the Nucleus Tractus Solitarii Modulates Glucose Homeostasis After Carotid Chemoreceptor Stimulati...
233
Chapter 33 Hydrogen Sul fi de Acting at the Carotid Body and Elsewhere in the Organism
240
Chapter 34 Purinergic Modulation of Carotid Body Glomus Cell Hypoxia Response During Postnatal Maturation in Rats
249
Chapter 35 Serotonin Dynamics and Actions in the Rat Carotid Body Preliminary Findings
254
Chapter 36 Human Carotid Body HIF and NGB Expression During Human Development and Aging
265

Chapter 9 TimeCourse of Ventilation Arterial and Pulmonary CO 2 Tension During CO 2 Increase in Humans
63
Chapter 10 Oxygen Sensitive Synaptic Neurotransmission in AnoxiaTolerant Turtle Cerebrocortex
71
Chapter 11 Ion Channel Regulation by the LKB1AMPK Signalling Pathway The Key to Carotid Body Activation by Hypoxia and Metabolic Homeos...
80
Chapter 12 Anoxia Response in Physiological Potassium of the Isolated Inspiratory Center in Calibrated Newborn Rat Brainstem Slices
91
Chapter 13 Hypoxic Redistribution of Iron and Calcium in the Cat Glomus Cells
99
Chapter 14 Acute Hypoxia Does Not In fl uence Intracellular pH in Isolated Rat Carotid Body Type I Cells
105
Chapter 15 Hydrogen Sul fi de H 2 S A Physiologic Mediator of Carotid Body Response to Hypoxia
108
Chapter 16 The Retrotrapezoid Nucleus and Breathing
115
Chapter 17 The Interaction Between Low Glucose and Hypoxia in the in vitro Rat Carotid Body
123
Chapter 18 Do the Carotid Bodies Modulate Hypoglycemic Counterregulation and Baroreflex Control of Blood Pressure In Humans?
128
Chapter 19 Shifting from Hypoxia to Hyperoxia to Assess the Peripheral Chemosensory Drive of Ventilation
137
Chapter 20 CO 2 Signaling in Chemosensory Neuroepithelial Cells of the Zebra fi sh Gill Filaments Role of Intracellular Ca 2+ and pH
143
Chapter 21 Hyperplasia of Pulmonary Neuroepithelial Bodies NEB in Lungs of Prolyl Hydroxylase 1PHD1 De fi cient Mice
149
Chapter 22 PrecisionCut Vibratome Slices Allow Functional Live Cell Imaging of the Pulmonary Neuroepithelial Body Microenvironment in Fetal M...
156
Chapter 23 Oxygen Sensitivity of Gill Neuroepithelial Cells in the AnoxiaTolerant Goldfish
167
Chapter 24 Interaction of Hypoxia and Core Temperature Potential Role of TRPV1
173
Chapter 25 Neonatal Intermittent Hypoxia Induces Persistent Alteration of Baroreflex in Adult Male Rats
179
Chapter 26 LPSInduced cFos Activation in NTS Neurons and Plasmatic Cortisol Increases in Septic Rats Are Suppressed by Bilateral Carotid Chemod...
185
Chapter 27 Developmental Regulation of Glucosensing in Rat Adrenomedullary Chromaffin Cells Potential Role of the K ATP Channel
191
Chapter 28 Contribution of In fl ammation on Carotid Body Chemosensory Potentiation Induced by Intermittent Hypoxia
199
Chapter 37 Propranolol Does Not Affect the Hindlimb Vasodilatation Elicited by Stimulation of Superior Laryngeal Nerve Paraganglia
272
Chapter 38 ATP Release from the Carotid Bodies of DBA2J and AJ Inbred Mouse Strains
279
Chapter 39 Effect of Oxygen on Phosphodiesterases PDE 3 and 4 Isoforms and PKA Activity in the Superior Cervical Ganglia
286
Chapter 40 Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat
295
Chapter 41 Upregulation of Pituitary Adenylate Cyclase Activating Polypeptide and Its Receptor Expression in the Rat Carotid Body in Chronic and I...
301
Chapter 42 Rabbit Ventilatory Responses to Peripheral Chemoexcitators Effects of Chronic Hypoxia
307
Chapter 43 Effect of Chronic Caffeine Intake on Carotid Body Catecholamine Dynamics in Control and Chronically Hypoxic Rats
315
Chapter 44 Effects of Cigarette Smoke and Chronic Hypoxia on Ventilation in Guinea Pigs Clinical Significance
325
Chapter 45 Some Re fl ections on Intermittent Hypoxia Does it Constitute the Translational Niche for Carotid Body Chemoreceptor Researchers?
333
Chapter 46 Role of CentralPeripheral Chemoreceptors and Their Interdependence in the Pathophysiology of Sleep Apnea
343
Chapter 47 Physiologic Basis for Intermittent Hypoxic Episodes in Preterm Infants
351
Chapter 48 Chronic Intermittent Hypoxia Increases Apnoea Index in Sleeping Rats
359
Chapter 49 Contribution of TASKLike Potassium Channels to the Enhanced Rat Carotid Body Responsiveness to Hypoxia
365
Chapter 50 Antioxidation and the Hypoxic Ventilatory Response
373
Chapter 51 Differential Regulation of Tyrosine Hydroxylase by Continuous and Intermittent Hypoxia
381
Chapter 52 Heart Failure and Carotid Body Chemoreception
386
Concluding Remarks
397
Index
402
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