Aspergillus and Aspergillosis

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Springer Science & Business Media, Apr 1, 1988 - Medical - 322 pages
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Species of aspergilli are common in man's environment and are responsible for a wide spectrum of human and animal disease, ranging in animals from mycotic abortion to aflatoxicosis and in humans from localized colonization of the ear or skin to life-threatening systemic infection of neutropenic patients. In recent times, invasive aspergillosis has become increasingly important as a cause of morbidity and death, initially in patients receiving immunosuppression prior to organ transplantation, and latterly in haematologic patients rendered neutropenic by underlying disease or chemotherapy. In some centres, the condition has been recorded in more than 40% of patients dying with acute leukaemia. Laboratory diagnostic procedures are not always helpful and the diagnosis depends largely on clinical parameters. The clinician is faced with yet another problem, that of management. At present, antifungal therapy of invasive aspergillosis can be largely ineffectual, and the mortality rate remains unacceptably high. Since Aspergillus fumigatus was first described almost 125 years ago, several other pathogenic species have been recognized. The marked biosynthetic abilities and varied mechanisms of gene recombination of aspergilli have long commanded attention in food technology and genetics. Their equally varied abilities to cause disease have attracted the interest of toxicologists, allergists and physicians concerned with infectious diseases.
 

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Contents

KEYNOTE LECTURE ASPERGILLUS IN MAN
1
DESCRIPTION EPIDEMIOLOGY ECOLOGY DIAGNOSIS
9
DIAGNOSIS AND DESCRIPTION OF THE GENUS
11
EPIDEMIOLOGY OF ASPERGILLOSIS
23
ECOLOGY OF ASPERGILLUS SPECIES IN THE HUMAN ENVIRONMENT
35
SERODIAGNOSIS OF ASPERGILLOSIS
43
IMMUNOLOGY PATHOLOGY HOST DEFENCE
73
THE IMMUNOLOCIC SIGNIFICANCE OF ASPERGILLUE FUNICATUS FRACTIONS
75
POLYENE MACROLIDE ANTIBIOTICS
147
THE MECHANISM OF ACTION OF AMPHOTERICIN
161
MODE OF ACTION OF 5FLUOROCYTOSINE IN ASPERGILLUS FUMIGATUS
165
THE MOLECULAR BASIS FOR ITRACONAZOLES ACTIVITY AGAINST ASPERGILLUS FUMIGATUS
171
EFFECTS OF AZOLES
199
TREATMENT OF ASPERGILLOSIS AND ASPERGILLOMA
213
INVITRO AND INVIVO MODELS TO STUDY THE ACTIVITY OF ANTIFUNGALS AGAINST ASPERGILLUS
215
A HISTORY OF THE TREATMENT OF ASPERGILLOSIS
229

ALLERGIC ASPERGILLOSIS
87
PULMONARY ASPERGILLOSIS THE CLINICAL SPECTRUM
97
ASPERGILLOMA
107
ROLE OF THE PHAGOCYTE IN HOST DEFENSE AGAINST ASPERGILLOSIS
115
HOST TISSUE RESPONSES TO PATHOGENIC AND NONPATHOGENIC FUNGI INCLUDING ASPERGILLI
121
ASPERGILLUS PROTEASES AND ASPERGILLOSIS
129
BIOCHEMISTRY MECHANISMS OF ACTION MORPHOLOGY
133
STEROL METABOLISM IN ASPERGILLUS SPECIES
135
THE TREATMENT OF ASPERGILLOSIS WITH AZOLE DERIVATIVES
243
ITRACONAZOLE IN THE TREATMENT OF PULMONARY ASPERGILLOMA AND CHRONIC PULMONARY ASPERGILLOSIS
253
TREATMENT OF ASPERGILLUS KERATITIS WITH IMIDAZOLES AND RELATED COMPOUNDS
267
PROPHYLAXIS
281
PROPHYLAXIS OF ASPERGILLOSIS IN IMMUNOCOMPROMISED PATIENTS
283
ENVIRONMENTAL CONTROL
289
SUMMARY AND OUTLOOK
299
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Page 264 - H., (1985), The action of itraconazole and ketoconazole on growth and sterol synthesis in Aspergillus fumigatus and Aspergillus niger.
Page 132 - Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus: observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes.

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