Aspergillus Fumigatus: Biology, Clinical Aspects, and Molecular Approaches to Pathogenicity
Axel A. Brakhage, Bernhard Jahn, Axel Schmidt
Karger, Jan 1, 1999 - Medical - 221 pages
Aspergillus fumigatus has become one of the most important fungal human pathogens in industrialized countries. It causes different diseases like allergic bronchopulmonary aspergillosis, aspergilloma, and invasive aspergillosis depending on the underlying disease as well as the immunological status of the host. A. fumigatus is today one of the most threatening aerial fungal pathogens because nosocomially acquired invasive aspergillosis typically occurs in the treatment setting for hematological malignancy. With the increasing number of immuno-compromised individuals such as AIDS and cancer patients or transplant recipients, systemic Aspergillus infections are often life-threatening with a very high mortality rate even after anti-mycotic therapy. This book provides a comprehensive overview of the classical and molecular techniques used in the isolation, analysis, diagnosis, and the identification of potential virulence factors of A. fumigatus. The pathogenesis and clinical presentation, the epidemiology and the therapy of A. fumigatus infections are discussed extensively. Compiling the most up-to-date information available, this volume will be a useful reference source for both clinical investigators and basic research scientists.
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The Genus Aspergillus with Special Regard to the Aspergillus fumigatus
Pathogenesis and Clinical Presentation of Aspergillosis
Epidemiology and Molecular Basis of the Involvement of Aspergillus
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ABPA acid activity agar allergens allergic bronchopulmonary aspergillosis AmBisome amphotericin antibodies antifungal antigen Antimicrob Agents Chemother Aspergillus fumigatus Aspergillus infections Aspergillus nidulans Aspergillus species assay binding Biol Brakhage cDNA characterization chitin synthase chronic chsC chsD Clin Infect Clin Microbiol clinical cloning conidia conidiophores Crameri CsmA culture Denning DW diagnosis disease disruption enzyme factors fibrinogen fibronectin filamentous fungi flavus fumigatus conidia fungal infections fungi fungus galactomannan gene encoding Genet genomic genus Aspergillus Holden DW host human hyphae identification immunocompromised immunocompromised patients Immunol incubation Infect Immun invasive aspergillosis invasive pulmonary aspergillosis isolates itraconazole laminin Latgé JP lesions lung macrophages MICs molecular molecules Monod mutants Mycol Mycoses Neosartorya neutrophils pastoris pathogenic peptide pg/ml phage pigment Pitt JI pksP polymerase chain reaction protein rAsp f recombinant Samson RA selectable marker sequence serum spores strains studies teleomorphs therapy tissue transformation treatment virulence vitro wild-type yeast