Aspirin and Related Drugs

Front Cover
Kim D. Rainsford
CRC Press, Apr 19, 2016 - Medical - 800 pages
2 Reviews
Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin.

Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation.

With extensive data and literature covering a broad field, this is the definitive reference on the actions and applications of aspirin, salicylates, and related drugs. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will find this resource useful in their daily work. It will also be valuable to pharmaceutical companies and researchers in the development of newer agents and novel applications.
 

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Contents

1 History and Development of the Salicylates
1
the Evolution of Analgesics and Antipyretics
25
3 Occurrence Properties and Synthetic Developments of the Salicylates
45
4 Pharmacokinetics and Metabolism of the Salicylates
97
5 Metabolism and Pharmacokinetics of Ibuprofen
157
6 Pharmacokinetics and Metabolism of Paracetamol Acetaminophen
181
7 Pharmacology and Biochemistry of Salicylates and Related Drugs
215
8 Side Effects and Toxicology of the Salicylates
367
9 Reye8217s Syndrome and Aspirin
555
10 Salicylates in the Treatment of Acute Pain
587
11 Acetylsalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases
619
12 Use of Salicylates in Rheumatic and Related Conditions
635
13 Aspirin and NSAIDs in the Prevention of Cancer Alzheimer8217s Disease and other Novel Therapeutic Actions
707
Index
757
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