Aspirin and Related Drugs
Kim D. Rainsford
CRC Press, Apr 19, 2016 - Medical - 800 pages
Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin.
Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation.
With extensive data and literature covering a broad field, this is the definitive reference on the actions and applications of aspirin, salicylates, and related drugs. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will find this resource useful in their daily work. It will also be valuable to pharmaceutical companies and researchers in the development of newer agents and novel applications.
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the Evolution of Analgesics and Antipyretics
3 Occurrence Properties and Synthetic Developments of the Salicylates
4 Pharmacokinetics and Metabolism of the Salicylates
5 Metabolism and Pharmacokinetics of Ibuprofen
6 Pharmacokinetics and Metabolism of Paracetamol Acetaminophen
7 Pharmacology and Biochemistry of Salicylates and Related Drugs
8 Side Effects and Toxicology of the Salicylates
9 Reye8217s Syndrome and Aspirin
10 Salicylates in the Treatment of Acute Pain
11 Acetylsalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases
12 Use of Salicylates in Rheumatic and Related Conditions
13 Aspirin and NSAIDs in the Prevention of Cancer Alzheimer8217s Disease and other Novel Therapeutic Actions
absorption acetaminophen acetyl acetylsalicylic acid activity acute adjuvant American Journal analgesic antipyretic aspirin aspirin and salicylate aspirin-induced assay Bayer Biochemical Pharmacology blood British Journal Brune cells cent chemical chronic clearance Clinical Pharmacology compared cyclo-oxygenase derivatives diflunisal disease dosage doses of aspirin effects of aspirin effects of salicylates enantiomers enzyme esters Experimental factors gastric mucosa Gastroenterology gastrointestinal glucuronide human ibuprofen increased indomethacin induced inflammation inflammatory inhibition inhibitors inhibitory effects interactions intestinal Journal of Clinical Journal of Pharmaceutical Journal of Pharmacology Journal of Pharmacy lesions Medical mesalazine metabolism metabolites methyl salicylate mitochondrial mucosal mucosal damage non-steroidal anti-inflammatory drugs NSAIDs observed oral pain relief paracetamol pathways patients PGE2 pharmacokinetics Pharmacology and Therapeutics placebo plasma concentrations platelet potential production prostaglandin protein Rainsford reactions reduced renal Reye’s syndrome rheumatic rheumatoid arthritis salicylic acid salicylurate serum Smith sodium salicylate studies synovial synthesis therapy tion tissue toxicity treatment ulceration ulcerogenic vitro vivo Whitehouse